Therapeutic target discovery and validation programme & the systems microscopy initiative

治疗靶点发现和验证计划

• 批准号: MC_UU_12022/8
• 负责人: Alessandro Esposito
• 金额: $ 751.27万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12022%2F8
• 关键词: Therapeutic; target; discovery; validation; programme

The discovery and development of new drugs for human diseases is a major scientific priority worldwide, but the process is beset with challenges that make it difficult, expensive and protracted. Our work exploits advances in our understanding of the molecular circuits controlling normal and diseased cells to identify and validate new targets for the next generation of medicines. We are also developing new methods for microscopy to better understand the effect of new medicines on diseased cells.

人类疾病新药的发现和开发是世界范围内的一项重大科学优先事项，但这一过程充满了挑战，使其变得困难、昂贵和旷日持久。我们的工作利用我们对控制正常和疾病细胞的分子电路的理解方面的进展，来识别和验证下一代药物的新靶点。我们还在开发新的显微镜方法，以更好地了解新药对疾病细胞的影响。

项目成果

Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.

• DOI: 10.1039/c7cc05379g
• 发表时间: 2017-08-17
• 期刊: Chemical communications (Cambridge, England)
• 作者: Cole DJ;Janecek M;Stokes JE;Rossmann M;Faver JC;McKenzie GJ;Venkitaraman AR;Hyvönen M;Spring DR;Huggins DJ;Jorgensen WL
• 通讯作者: Jorgensen WL

Checkpoint non-fidelity induces a complex landscape of lineage fitness after DNA damage

检查点不保真会在 DNA 损伤后引发复杂的谱系适应性景观

• DOI: 10.1101/431486
• 发表时间: 2018
• 作者: Campbell C

Chromosome instability and carcinogenesis: insights from murine models of human pancreatic cancer associated with BRCA2 inactivation.

• DOI: 10.1016/j.molonc.2013.10.005
• 发表时间: 2014-03
• 期刊: Molecular oncology
• 影响因子: 6.6
• 作者: Cassidy LD;Liau SS;Venkitaraman AR
• 通讯作者: Venkitaraman AR