Oesophago-gastric adenocarcinoma: understanding disease pathogenesis and applications to earlier diagnosis

食管胃腺癌：了解疾病发病机制及其在早期诊断中的应用

• 批准号: MC_UU_12022/2
• 负责人: Rebecca Fitzgerald
• 金额: $ 497.07万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12022%2F2
• 关键词: Oesophago; gastric; adenocarcinoma; understanding; disease

Cancer of the gullet (oesophagus) is increasing rapidly in the western world and has a very poor outcome unless diagnosed early. My research laboratory is focussed on better understanding how this cancer develops so that we can find better tools for diagnosis and treatment. We have made very good progress in developing a new diagnostic test called the Cytosponge. This comprises a cell collection device which can be given in the GP surgery and avoids endoscopy. The collected cells are then tested in the laboratory for protein and gene alterations that we have identified suggestive of precancerous changes. This test is now being developed for routine clinical use.

食道癌(食道癌)在西方世界迅速增长，除非及早诊断，否则预后非常差。我的研究实验室专注于更好地了解这种癌症是如何发展的，以便我们能够找到更好的诊断和治疗工具。我们在开发一种名为细胞学的新诊断测试方面取得了非常好的进展。这包括可以在GP手术中给予并避免内窥镜检查的细胞收集装置。然后，收集的细胞在实验室中进行蛋白质和基因变化测试，我们已经确定这些变化暗示着癌前病变。这项测试目前正在开发用于常规临床用途。

项目成果

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

• DOI: 10.1038/s41467-020-18151-y
• 发表时间: 2020-09-21
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Bailey MH;Meyerson WU;Dursi LJ;Wang LB;Dong G;Liang WW;Weerasinghe A;Li S;Li Y;Kelso S;MC3 Working Group;PCAWG novel somatic mutation calling methods working group;Saksena G;Ellrott K;Wendl MC;Wheeler DA;Getz G;Simpson JT;Gerstein MB;Ding L;PCAWG Consortium
• 通讯作者: PCAWG Consortium

Glucose transporter 1 expression as a marker of prognosis in oesophageal adenocarcinoma.

葡萄糖转运蛋白 1 表达作为食管腺癌预后的标志物。

• DOI: 10.17863/cam.47040
• 发表时间: 2018
• 作者: Blayney J

DNA methylation as an adjunct to histopathology to detect prevalent, inconspicuous dysplasia and early-stage neoplasia in Barrett's esophagus.

• DOI: 10.1158/1078-0432.ccr-12-2880
• 发表时间: 2013-02-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Alvi MA;Liu X;O'Donovan M;Newton R;Wernisch L;Shannon NB;Shariff K;di Pietro M;Bergman JJ;Ragunath K;Fitzgerald RC
• 通讯作者: Fitzgerald RC

The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation.

• DOI: 10.1136/gutjnl-2013-306171
• 发表时间: 2015-01
• 期刊: Gut
• 影响因子: 24.5
• 作者: Barbera M;di Pietro M;Walker E;Brierley C;MacRae S;Simons BD;Jones PH;Stingl J;Fitzgerald RC
• 通讯作者: Fitzgerald RC