ETS-1 和 ETS-2 原癌基因功能的转基因小鼠模型系统-猫眼课题宝

ETS-1 和 ETS-2 原癌基因功能的转基因小鼠模型系统

批准号：

5201517

负责人：

J LAUTENBERGER

金额：

$0.0万

依托单位：

DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/5201517

关键词：

bone marrow cytokine receptors gene expression genetic promoter element genetic regulation genetically modified animals hematopoiesis interleukin 3 laboratory mouse megakaryocytes metallothionein protooncogene spleen tissue /cell culture transcription factor

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英文摘要

The effect of transgene expression on the regulation of hematopoiesis was examined in transgenic mice in which the Ets2 gene was driven by the mouse metallothionein promoter. It has been found that transgene expression results in an increase in the number of cells from bone marrow and spleen capable of forming colonies in semisolid media containing IL-3. The transgenic mice were found to have a higher percentage of megakaryocytes in their bone marrow than control animals. Bone marrow cultures derived from transgenic animals express higher levels of the c-mpl gene as compared to normal controls. c-mpl codes for the receptor for the platelet-inducing cytokine, thrombopoietin.

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