BIOCHEMICAL AND FUNCTIONAL PROPERTIES OF THE ETS PROTO-ONCOGENES
ETS 原癌基因的生化和功能特性
基本信息
- 批准号:5201515
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AIDS DNA binding protein chemical binding gene expression genetic enhancer element genetic promoter element genetic regulation human immunodeficiency virus 1 human immunodeficiency virus 2 human tissue messenger RNA molecular site nucleic acid repetitive sequence nucleotides oncoproteins protein structure function protooncogene provirus simian immunodeficiency virus transcription factor
项目摘要
The human immunodeficiency viruses (HIV-1 and HIV-2), along with their
simian counterpart, simian immunodeficiency virus (SIV), belong to the
lentivirus family and are the etiological agents of acquired immune
deficiency syndrome (AIDS). The regulation of HIV-1 and HIV-2 mRNA
expression is determined by cis-regulatory sequences located in the long
terminal repeat (LTR) region of the provirus. The HIV-1 LTR contains a
core enhancer located at -79 to -109 bp, which has overlapping NFkappaB
and ETS binding sites (EBS) (GGGACTTTCC) in a direct repeat
configuration.
An examination of promoters and enhancers that contain dual or multimeric
EBS reveals that two distinct orientations exist for EBS: i) direct, in
which the purine rich DNA strand has a linear, "head to tail"
orientation, and ii) palindromic, in which the EBS are found to exist in
a "head to head" orientation. The spacing between the two EBS cores in
the HIV-1 enhancer is ten nucleotides, however, the distance between two
EBS cores varies in different promoters.
人类免疫缺陷病毒(HIV-1和HIV-2),以及它们的
项目成果
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J LAUTENBERGER其他文献
J LAUTENBERGER的其他文献
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{{ truncateString('J LAUTENBERGER', 18)}}的其他基金
REAL-TIME ASSESSMENT OF MACROMOLECULAR INTERACTIONS BY SURFACE PLASMON RESONANCE
通过表面等离子共振实时评估大分子相互作用
- 批准号:
5201598 - 财政年份:
- 资助金额:
-- - 项目类别:
MOLECULAR ASPECTS OF COLON EPITHELIUM DIFFERENTIATION AND TUMOR FORMATION
结肠上皮分化和肿瘤形成的分子方面
- 批准号:
3752747 - 财政年份:
- 资助金额:
-- - 项目类别:
MOLECULAR MARKERS OF HUMAN LIVER CANCER-NOVEL GENES DIFFERENTIALLY EXPRESSED
人类肝癌的分子标记——差异表达的新基因
- 批准号:
5201562 - 财政年份:
- 资助金额:
-- - 项目类别:
TRANSGENIC MOUSE MODEL SYSTEM FOR THE ETS-1 AND ETS-2 PROTO-ONCOGENE FUNCTION
ETS-1 和 ETS-2 原癌基因功能的转基因小鼠模型系统
- 批准号:
5201517 - 财政年份:
- 资助金额:
-- - 项目类别:
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