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STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR

STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR
通过核磁共振对艾滋病蛋白进行结构研究
批准号：
5201951
负责人：
A M GRONENBORN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5201951
关键词：
DNA binding protein RNA binding protein cytokine genetic regulatory element human immunodeficiency virus 1 interleukin 4 interleukin 8 nuclear magnetic resonance spectroscopy nucleocapsid protein structure transcription factor virus protein

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中文摘要
翻译
已经就与以下方面有关的一些结构问题开展了工作 来自艾滋病毒-L病毒的蛋白质。其中包括DNA结合 整合酶结构域、NEF蛋白和p7核衣壳蛋白。 二聚体DNA结合的高分辨三维结构 确定了HIV-L整合酶的结构域。此外，还应努力 转录因子双锌结合区的复合体 GATA-L和ETS-L转录因子及其同源靶点 网站正在建设中。
英文摘要
Work has been carried out on a number of structural problems related to proteins derived from the HIV-l virus. These include the DNA binding domain of the integrase, the NEF protein and the p7 nucleocapsid protein. The high resolution three-dimensional structure of the dimeric DNA binding domain of HIV-l integrase has been determined. In addition, work on complexes of a double zinc binding domain of the transcription factor GATA-l and the ETS-l transcription factor with their cognate DNA target sites are underway.
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STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES IN SOLUTION BY NMR
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
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