INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
批准号:
3754177
负责人:
A M GRONENBORN
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
本实验室整体研究的目标集中在
英文摘要
The objective of the overall research in this laboratory is centered on
achieving as complete a description as possible for the structures of
peptides, proteins, nucleic acids and their complexes in solution,
principally by NMR spectroscopy. At present particular emphasis is being
placed on developing approaches which allow the investigation of larger
and complex systems as well as increase the precision with which these
solution structures can be obtained, studies aimed at correlating
structure and function, and experiments aimed at investigating protein
folding.
Structures for several proteins have been determined and analyzed. These
include oxidized and reduced human thioredoxin, the oligomerization
domain of p53, the cytokine hMIP-1-beta, and the Ascaris trypsin
inhibitor. These studies have exploited many novel 3D and 4D
heteronuclear NMR experiments to dramatically increase spectral
resolution and thereby resolve assignment ambiguities in larger proteins.
The site of interaction of interleukin-8 with the N-terminal cytoplasmic
portion of its cell surface receptor has been identified, and the
dynamics of the IgG binding domain of Streptococcal G have been
investigated. Finally, the folding pathway and kinetics of the highly
stable small IgG binding domain of Streptococcal protein G has been
studied.
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INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
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批准号:5201953
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A M GRONENBORN
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依托单位:
STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR
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批准号:2572978
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A M GRONENBORN
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依托单位:
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES IN SOLUTION BY NMR
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批准号:3875845
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A M GRONENBORN
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依托单位:
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
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批准号:6161937
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:A M GRONENBORN
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依托单位:
STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR
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批准号:3754175
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A M GRONENBORN
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依托单位:
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
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批准号:3839839
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:A M GRONENBORN
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依托单位:
STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR
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批准号:6161935
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:A M GRONENBORN
-
依托单位:
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
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批准号:2572980
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A M GRONENBORN
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依托单位:
STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR
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批准号:5201951
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:A M GRONENBORN
-
依托单位:
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
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批准号:3776284
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A M GRONENBORN
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依托单位:
海外基金