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STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR

STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR
通过核磁共振对艾滋病蛋白进行结构研究
批准号：
2572978
负责人：
A M GRONENBORN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/2572978
关键词：
AIDS DNA binding protein HIV envelope protein HIV envelope protein gp41 human immunodeficiency virus human immunodeficiency virus 1 integrase nuclear magnetic resonance spectroscopy nucleocapsid protein structure structural biology

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中文摘要
翻译
已经就一些相关的结构问题开展了工作 来自HIV-1病毒的蛋白质。其中包括DNA 整合酶、Nef蛋白和p7的结合域 核衣壳蛋白。高分辨率的三维 HIV-1整合酶二聚体DNA结合区的结构 测定了可溶性Nef蛋白变异体。此外，工作 HIV整合酶N端DNA结合区及其三聚体的研究 正在形成HIV-1包膜糖蛋白GP41的亚区。
英文摘要
Work has been carried out on a number of structural problems related to proteins derived from the HIV-1 virus. These include the DNA binding domain of the integrase, the Nef protein and the p7 nucleocapsid protein. The high resolution three-dimensional structures of the dimeric DNA binding domain of HIV-1 integrase and a soluble Nef protein variant have been determined. In addition, work on the n-terminal DNA binding domain of HIV integrase and the trimer forming subdomain of the HIV-1 envelope glycoprotein GP41 is underway.
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INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES IN SOLUTION BY NMR
INVESTIGATIONS OF MACROMOLECULAR STRUCTURES AND DYNAMICS IN SOLUTION BY NMR
STRUCTURAL STUDIES OF AIDS PROTEINS BY NMR
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