MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

原发性甲状旁腺功能亢进症(HPT)，一种常见的内分泌疾病，可 引起明显的发病率，可能是由于良性肿瘤的单一 甲状旁腺(腺瘤)或多发性甲状旁腺(增生)， 罕见的甲状旁腺恶性肿瘤(癌)。这个 甲状旁腺肿瘤的病因尚未确定。与其他产品一样 各种形式的肿瘤，甲状旁腺肿瘤可能是由于遗传性的 (胚系突变)和/或获得性(体细胞突变)缺陷 特定的基因。病因性遗传缺陷可能包括不适当的 转化癌基因的表达和/或肿瘤的表达缺失 “抑制”基因。手术切除甲状旁腺的可行性 来自散发性和遗传性疾病患者的肿瘤允许 美国将寻找可能涉及的肿瘤特异性基因异常 在甲状旁腺肿瘤的发展过程中。

Primary hyperparathyroidism (HPT), a common endocrine disorder that can cause significant morbidity, may be due to benign neoplasia of a single parathyroid gland (adenoma) or multiple parathyroid glands (hyperplasia), and rarely, to malignant neoplasia of a parathyroid gland (carcinoma). The etiology of parathyroid neoplasia has not been defined. As with other forms of neoplasia, parathyroid tumors are presumably due to inherited (germ-line mutation) and/or acquired (somatic mutation) defects in specific genes. Etiologic genetic defects could include inappropriate expression of transforming "oncogenes" and/or loss of expression of tumor "suppressor" genes. The availability of surgically resected parathyroid tumors from patients with sporadic and hereditary forms of disease allows us to search for tumor-specific genetic abnormalities that may be involved in development of parathyroid neoplasia.