MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

甲状旁腺肿瘤病因的分子生物学研究

基本信息

项目摘要

Primary hyperparathyroidism (HPT), a common endocrine disorder that can cause significant morbidity, may be due to benign neoplasia of a single parathyroid gland (adenoma) or multiple parathyroid glands (hyperplasia), and rarely, to malignant neoplasia of a parathyroid gland (carcinoma). The etiology of parathyroid neoplasia has not been defined. As with other forms of neoplasia, parathyroid tumors are presumably due to inherited (germ-line mutation) and/or acquired (somatic mutation) defects in specific genes. Etiologic genetic defects could include inappropriate expression of transforming "oncogenes" and/or loss of expression of tumor "suppressor" genes. The availability of surgically resected parathyroid tumors from patients with sporadic and hereditary forms of disease allows us to search for tumor-specific genetic abnormalities that may be involved in development of parathyroid neoplasia.
原发性甲状旁腺功能亢进(HPT)是一种常见的内分泌疾病, 引起显著的发病率,可能是由于良性肿瘤的单一 甲状旁腺(腺瘤)或多发性甲状旁腺(增生), 很少发生甲状旁腺恶性肿瘤(癌)。的 甲状旁腺肿瘤的病因尚未确定。与其他 甲状旁腺肿瘤是一种肿瘤,可能是由于遗传 (生殖系突变)和/或获得性(体细胞突变)缺陷, 特定基因病因遗传缺陷可能包括不适当的 转化“癌基因”的表达和/或肿瘤表达的丧失 “抑制”基因。手术切除甲状旁腺的可行性 来自散发性和遗传性疾病患者的肿瘤允许 我们寻找可能涉及的肿瘤特异性遗传异常, 甲状旁腺肿瘤的发生。

项目成果

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A SPIEGEL其他文献

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{{ truncateString('A SPIEGEL', 18)}}的其他基金

STUDIES ON PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS
假性甲状旁腺功能减退症及相关疾病的研究
  • 批准号:
    3840499
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS
作为受体-效应器偶联剂的鸟嘌呤核苷酸结合蛋白
  • 批准号:
    3776957
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS
作为受体-效应器偶联剂的鸟嘌呤核苷酸结合蛋白
  • 批准号:
    3754548
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS
作为受体-效应器偶联剂的鸟嘌呤核苷酸结合蛋白
  • 批准号:
    5202010
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA
甲状旁腺肿瘤病因的分子生物学研究
  • 批准号:
    3918280
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA
甲状旁腺肿瘤病因的分子生物学研究
  • 批准号:
    3855431
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
STUDIES ON NEPHROGENIC DIABETES INSIDIPUS
肾性尿崩症的研究
  • 批准号:
    3840502
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
STUDIES ON MCCUNE-ALBRIGHT SYNDROME
麦库恩-奥尔布赖特综合征的研究
  • 批准号:
    3754550
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
STUDIES ON A CALCIUM SENSING RECEPTOR
钙传感受体的研究
  • 批准号:
    3754521
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
STUDIES ON PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS
假性甲状旁腺功能减退症及相关疾病的研究
  • 批准号:
    3918282
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

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