MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA
甲状旁腺肿瘤病因的分子生物学研究
基本信息
- 批准号:5202009
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Primary hyperparathyroidism (HPT), a common endocrine disorder that can
cause significant morbidity, may be due to benign neoplasia of a single
parathyroid gland (adenoma) or multiple parathyroid glands (hyperplasia),
and rarely, to malignant neoplasia of a parathyroid gland (carcinoma). The
etiology of parathyroid neoplasia has not been defined. As with other
forms of neoplasia, parathyroid tumors are presumably due to inherited
(germ-line mutation) and/or acquired (somatic mutation) defects in
specific genes. Etiologic genetic defects could include inappropriate
expression of transforming "oncogenes" and/or loss of expression of tumor
"suppressor" genes. The availability of surgically resected parathyroid
tumors from patients with sporadic and hereditary forms of disease allows
us to search for tumor-specific genetic abnormalities that may be involved
in development of parathyroid neoplasia.
原发性甲状旁腺功能亢进(HPT)是一种常见的内分泌疾病,
引起显著的发病率,可能是由于良性肿瘤的单一
甲状旁腺(腺瘤)或多发性甲状旁腺(增生),
很少发生甲状旁腺恶性肿瘤(癌)。的
甲状旁腺肿瘤的病因尚未确定。与其他
甲状旁腺肿瘤是一种肿瘤,可能是由于遗传
(生殖系突变)和/或获得性(体细胞突变)缺陷,
特定基因病因遗传缺陷可能包括不适当的
转化“癌基因”的表达和/或肿瘤表达的丧失
“抑制”基因。手术切除甲状旁腺的可行性
来自散发性和遗传性疾病患者的肿瘤允许
我们寻找可能涉及的肿瘤特异性遗传异常,
甲状旁腺肿瘤的发生。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('A SPIEGEL', 18)}}的其他基金
STUDIES ON PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS
假性甲状旁腺功能减退症及相关疾病的研究
- 批准号:
3840499 - 财政年份:
- 资助金额:
-- - 项目类别:
GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS
作为受体-效应器偶联剂的鸟嘌呤核苷酸结合蛋白
- 批准号:
3776957 - 财政年份:
- 资助金额:
-- - 项目类别:
GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS
作为受体-效应器偶联剂的鸟嘌呤核苷酸结合蛋白
- 批准号:
3754548 - 财政年份:
- 资助金额:
-- - 项目类别:
GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS
作为受体-效应器偶联剂的鸟嘌呤核苷酸结合蛋白
- 批准号:
5202010 - 财政年份:
- 资助金额:
-- - 项目类别:
MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA
甲状旁腺肿瘤病因的分子生物学研究
- 批准号:
3918280 - 财政年份:
- 资助金额:
-- - 项目类别:
MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA
甲状旁腺肿瘤病因的分子生物学研究
- 批准号:
3855431 - 财政年份:
- 资助金额:
-- - 项目类别:
STUDIES ON PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS
假性甲状旁腺功能减退症及相关疾病的研究
- 批准号:
3918282 - 财政年份:
- 资助金额:
-- - 项目类别:
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