Neural mechanisms for inhibitory control over attention and working memory

抑制控制注意力和工作记忆的神经机制

• 批准号: MR/J009024/1
• 负责人: Mark Stokes
• 金额: $ 134万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FJ009024%2F1
• 关键词: Neural; mechanisms; inhibitory; control; over

Our everyday view of the world is necessarily biased: we focus our attention on information that is most relevant to our current goals, and ignore behaviourally irrelevant information. Without such bias, we would be lost in a world of information-overload, unable to accomplish even the simplest tasks. This research explores how the brain controls bias to optimise goal-directed behaviour. Over a series of experiments, activity in the human brain will be measured, and perturbed, to test whether a common brain mechanism is responsible for controlling the ability to focus on goal-relevant visual information as well as ignoring irrelevant, or distracting visual input. This research will also explore how these perceptual biases shape memory formation, and conversely, how our memories in turn create new bias patterns. Finally, this research will also explore how individuals differ in their ability to focus on behaviourally relevant information, and/or suppress distractions. Of particular interest, these abilities will be related to personality traits associated with depression and anxiety, providing a foundation for further research into how cognitive control could play a role in psychiatric mood disorders.

我们对世界的日常看法必然是有偏见的：我们把注意力集中在与我们当前目标最相关的信息上，而忽略了行为上不相关的信息。如果没有这种偏见，我们将迷失在信息过载的世界中，甚至无法完成最简单的任务。这项研究探讨了大脑如何控制偏见以优化目标导向行为。在一系列实验中，人类大脑的活动将被测量和干扰，以测试是否有一种共同的大脑机制负责控制专注于目标相关视觉信息的能力，以及忽略无关或分散注意力的视觉输入。这项研究还将探索这些感知偏见如何塑造记忆的形成，以及反过来，我们的记忆如何反过来创造新的偏见模式。最后，本研究还将探讨个体在专注于行为相关信息和/或抑制分心的能力方面的差异。特别有趣的是，这些能力将与抑郁和焦虑相关的人格特征有关，为进一步研究认知控制如何在精神情绪障碍中发挥作用提供了基础。

项目成果

Decoding visual colour from scalp electroencephalography measurements.

• DOI: 10.1016/j.neuroimage.2021.118030
• 发表时间: 2021-08-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Hajonides JE;Nobre AC;van Ede F;Stokes MG
• 通讯作者: Stokes MG

Comparing the prioritisation of items and feature-dimensions in visual working memory

• DOI: 10.1101/863191
• 发表时间: 2019-12
• 期刊: bioRxiv
• 作者: Jasper E. Hajonides;F. van Ede;M. Stokes;A. Nobre

Dynamic construction of a coherent attentional state in a prefrontal cell population.

• DOI: 10.1016/j.neuron.2013.07.041
• 发表时间: 2013-10-02
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Kadohisa M;Petrov P;Stokes M;Sigala N;Buckley M;Gaffan D;Kusunoki M;Duncan J
• 通讯作者: Duncan J

Decoding the Influence of Anticipatory States on Visual Perception in the Presence of Temporal Distractors

解码存在时间干扰因素时预期状态对视觉感知的影响

• DOI: 10.1101/143123
• 发表时间: 2017
• 作者: Ede F