Centre for Health service and Academic Partnership in Translational eHealth Research (CHAPTER)

转化电子卫生研究中的卫生服务和学术合作中心（章节）

• 批准号: MR/K006584/1
• 负责人: Harry Hemingway
• 金额: $ 566.65万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK006584%2F1
• 关键词: Centre; Health; service; Academic; Partnership

CHAPTER's host institution, UCL, is part of an established Academic Health Science Centre (AHSC), which brings together university and NHS organisations. This partnership lies at heart of the vision of CHAPTER. UCL Partners is the only AHSC with a system wide partnership model (n=14 NHS Trusts), and is responsible for the primary, secondary and tertiary care for a population of about 5 million people. UCLP hosts the largest concentration of Biomedical Research Centres (3 at UCL: UCLH, Great Ormond Street Children's Hospital and Moorfields Eye Hospital and two Biomedical Research Units (UCL: dementia; QMUL: cardiovascular). We will align our research with this significant (£165m) NIHR investment. Bringing together three of UCLP's academic partners (UCL, LSHTM and QMUL), and the HPA, CHAPTER will integrate for the first time multiple areas of critical mass (>60 data sources and >30 cross Faculty research groups with informatics expertise) in order to deliver our vision of driving the next generation of population wide research for patient benefit. With support from the MRC led funding consortium, UCL will commit a further £4m to CHAPTER, providing sustainable posts (2 Chairs, 2 senior lecturers, 2 lecturers) and associated costs. Our NHS partners are investing significantly in new integration systems (across primary and secondary care), to drive improvements in the quality and safety of clinical care and this will enhance our ability to deliver impact across the whole translational cycle: from biological discovery including genomics and medical imaging, through innovative trials to improving clinical practice, service delivery, patient outcomes and public health. Specifically CHAPTER will: A answer important research questions, aligned with our BRCs: initially in cardiovascular medicine, maternal and child health, and infection. We will work with the Clinical Practice Research Datalink (CPRD) and expand linkages within and between national primary care sources, and the national EHR resources that we curate with >1m patients, including the national disease and procedure registries in cardiovascular disease, (UCL, NICOR), mother and child, and infection (HPA, LabBase). B establish a new informatics platform (i.e. a common approach) ensuring that data collected in different clinical systems can be securely and meaningfully integrated for our research. We will improve the quality of clinically collected data, by linking to initiatives to improve the quality of clinical care. We will develop new approaches to tackle data which are missing in clinical records, analyse free text and medical images. Our visualization initiatives will support clinicians in decision making (e.g. dashboards), engage researchers in the complexity and meanings of data, and engage patients and public (citizen science). C establish an Academy of Translational eHealth for inter-disciplinary training of clinicians, academics and those in enabling roles. Bringing together the training capacity of LSHTM (epidemiology and biostatistics) and UCL (health informatics, range of translational sciences) we will establish a new, cross-discipline, doctoral training programme, taught courses (undergraduate, masters and short course), career development and leadership development programmes.D implement consent as part of clinical care across UCL Partner organisations and develop innovative public engagement programmes. We will engage patients in the design and evaluation of our UCLP-wide consent initiative and establish a continuous cycle of engagement with the public in the co-design of research using electronic health records. Research grants submitted from CHAPTER will be influenced from the start by such public engagement activities. These four areas of work will lead to programme grant applications for further research for patient benefit as well as laying the foundation for extending CHAPTER research into other BRC priority clinical areas.

CHAPTER的主办机构，UCL，是一个既定的学术健康科学中心（AHSC），汇集了大学和NHS组织的一部分。这种合作关系是CHAPTER愿景的核心。UCL Partners是唯一一家拥有全系统合作伙伴模式的AHSC（n=14 NHS信托），负责为约500万人口提供初级、二级和三级护理。UCLP拥有最集中的生物医学研究中心（3个在UCL：UCLH，大奥蒙德街儿童医院和Moorfields眼科医院和两个生物医学研究单位（UCL：痴呆症; QMUL：心血管）。我们将把我们的研究与这项重大的（1.65亿英镑）NIHR投资保持一致。汇集了三个UCLP的学术合作伙伴（UCL，LSHTM和QMUL）和HPA，CHAPTER将首次整合多个临界质量领域（>60个数据源和>30个具有信息学专业知识的跨学院研究小组），以实现我们推动下一代人群研究的愿景，为患者造福。在MRC领导的资助财团的支持下，UCL将向CHAPTER进一步投入400万英镑，提供可持续的职位（2名主席，2名高级讲师，2名讲师）和相关费用。我们的NHS合作伙伴正在大力投资新的集成系统（涵盖初级和二级护理），以推动临床护理质量和安全性的提高，这将增强我们在整个转化周期中产生影响的能力：从生物发现，包括基因组学和医学成像，通过创新试验来改善临床实践、服务提供、患者结果和公共卫生。具体而言，第一章将：回答重要的研究问题，与我们的BRC保持一致：最初在心血管医学，孕产妇和儿童健康和感染。我们将与临床实践研究数据链（CPRD）合作，扩大国家初级保健资源内部和之间的联系，以及我们为超过100万患者策划的国家EHR资源，包括心血管疾病（UCL，NICOR），母婴和感染（HPA，LabBase）的国家疾病和程序登记。B建立一个新的信息学平台（即通用方法），确保在不同临床系统中收集的数据可以安全且有意义地整合用于我们的研究。我们将通过与提高临床护理质量的举措相联系，提高临床收集数据的质量。我们将开发新的方法来处理临床记录中缺失的数据，分析自由文本和医学图像。我们的可视化计划将支持临床医生进行决策（例如仪表板），让研究人员参与数据的复杂性和意义，并让患者和公众参与（公民科学）。C建立转化电子健康学院，为临床医生、学者和发挥促进作用的人提供跨学科培训。汇集LSHTM（流行病学和生物统计学）和UCL（健康信息学，转化科学的范围）的培训能力，我们将建立一个新的，跨学科，博士培训计划，授课课程（本科，硕士和短期课程），职业发展和领导力发展计划。我们将让患者参与我们的UCLP范围内的同意倡议的设计和评估，并建立一个与公众参与使用电子健康记录的研究共同设计的连续循环。从CHAPTER提交的研究赠款将从一开始就受到这种公众参与活动的影响。这四个领域的工作将导致计划拨款申请，以进一步研究患者的利益，以及奠定基础，将CHAPTER研究扩展到其他BRC优先临床领域。

项目成果

Patients' experiences and providers' observations on pain during intrauterine device insertion.

患者的经历和提供者对宫内节育器插入过程中疼痛的观察。

• DOI: 10.3109/13625187.2015.1031885
• 发表时间: 2015
• 期刊: the official journal of the European Society of Contraception
• 作者: Akintomide H

Obesity and type 2 diabetes in sub-Saharan Africans - Is the burden in today's Africa similar to African migrants in Europe? The RODAM study.

• DOI: 10.1186/s12916-016-0709-0
• 发表时间: 2016-10-21
• 期刊: BMC medicine
• 影响因子: 9.3
• 作者: Agyemang C;Meeks K;Beune E;Owusu-Dabo E;Mockenhaupt FP;Addo J;de Graft Aikins A;Bahendeka S;Danquah I;Schulze MB;Spranger J;Burr T;Agyei-Baffour P;Amoah SK;Galbete C;Henneman P;Klipstein-Grobusch K;Nicolaou M;Adeyemo A;van Straalen J;Smeeth L;Stronks K
• 通讯作者: Stronks K

A decision-theoretic planning approach for clinical practice guideline modelling

临床实践指南建模的决策理论规划方法

• DOI: 10.1109/bhi.2014.6864338
• 发表时间: 2014
• 作者: Acosta D

Ethnicity and the diagnosis gap in liver disease: a population-based study.

• DOI: 10.3399/bjgp14x682273
• 发表时间: 2014-11
• 期刊: The British journal of general practice : the journal of the Royal College of General Practitioners
• 作者: Alazawi W;Mathur R;Abeysekera K;Hull S;Boomla K;Robson J;Foster GR
• 通讯作者: Foster GR

Rationale and cross-sectional study design of the Research on Obesity and type 2 Diabetes among African Migrants: the RODAM study.

• DOI: 10.1136/bmjopen-2014-004877
• 发表时间: 2014-03-21
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Agyemang C;Beune E;Meeks K;Owusu-Dabo E;Agyei-Baffour P;Aikins Ad;Dodoo F;Smeeth L;Addo J;Mockenhaupt FP;Amoah SK;Schulze MB;Danquah I;Spranger J;Nicolaou M;Klipstein-Grobusch K;Burr T;Henneman P;Mannens MM;van Straalen JP;Bahendeka S;Zwinderman AH;Kunst AE;Stronks K
• 通讯作者: Stronks K