NOVEL THERAPIES AND DIAGNOSTICS FOR USE IN TREATMENT OF PERIDONTAL DISEASES

用于治疗牙周疾病的新疗法和诊断

• 批准号: 5210083
• 负责人: J M GOODSON
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5210083
• 关键词: bone regeneration; clinical trials; computer program /software; dental disorder chemotherapy; dental disorder diagnosis; disease /disorder model; disease /disorder prevention /control; dogs; drug adverse effect; electrical impedance; glucans; human subject; human therapy evaluation; insulinlike growth factor; laboratory mouse; laboratory rat; monocyte; neutrophil; pathologic bone resorption; periodontium disorder; platelet derived growth factor; polymers; rheumatoid arthritis; technetium

It is proposed that 4 novel therapies and 2 diagnostics be evaluated. Regeneration. The potential for stimulation of periodontal regeneration with application of the polypeptide growth factors will be tested in patients who have successfully completed periodontal therapy but have residual infrabony pockets. PDGF (platelet derived growth factor) and IGF (insulin derived growth factor) will be topically applied to the tooth root and alveolar defect. The response will be evaluated by a split-mouth comparison with application of the vehicle alone. Immunomodulators. Proof of principle studies will be conducted by "piggy- back" analysis of two placebo controlled studies in which patients with systemic disease are being treated by new types of therapy. This includes an investigation of patients who are being treated with the IL-1 receptor antagonist ANTRIL to relieve rheumatoid arthritis and a second group of patients being treated by the neutrophil stimulating carbohydrate. Betafectin for bone marrow failure. In each case, a subpopulation with coincident periodontal disease will be identified and clinical measures of change following therapy evaluated. In addition, animal studies are planned to examine the effect of these agents in model systems. Antibody Response to Scaling. The antibody response to scaling will be investigated in two types of tests. One study is designed to determine if clinical and microbiological effects associated with humoral antibody changes can be measured when sites are scaled elsewhere in the mouth. A second study is designed to determine if extensive scaling or disease active sites can be used to augment therapeutic and/or microbiologic response. Antibody Response to Scaling. The antibody response to scaling will be investigated in two types of tests. One study is designed to determine if clinical and microbiological effects associated with humoral antibody changes can be measured when sites are scaled elsewhere in the mouth. A second study is designed to determine if extensive scaling of disease active sites can be used to augment therapeutic and/or microbiologic response. Diagnostic. Electrical impedance of the periodontal pocket will be investigated in conjunction with the testing of an electronic pocket depth probe to determine potential utility in detecting conditions of pocket ulceration. Computer algorithms will be written and tested to develop methods to obtain quantitative information on periodontal bone loss by radiographic subtraction techniques under conditions of minimal standardization such as would occur in routine clinical practice.

建议对4种新疗法和2种诊断方法进行评价。 再生。促进牙周再生的潜力 随着多肽生长因子的应用，将在 成功完成牙周治疗的患者 残留的骨下口袋。血小板衍生生长因子与胰岛素样生长因子 (胰岛素衍生生长因子)将局部应用于牙齿 牙根和牙槽骨缺损处。反应将通过张开嘴巴进行评估 与单独使用车辆进行比较。 免疫调节剂。原则性证明研究将由“小猪-- 对两项安慰剂对照研究的Back“分析 全身性疾病正在通过新型疗法进行治疗。这包括 接受IL-1受体治疗的患者的调查 缓解类风湿性关节炎的拮抗剂ANTRIL和第二组 接受中性粒细胞刺激性碳水化合物治疗的患者。 贝伐他汀治疗骨髓衰竭。在每种情况下，都有一个具有 符合的牙周疾病将被识别和临床措施 治疗后变化的评估。此外，动物研究还包括 计划在模型系统中检查这些代理的效果。 对结垢的抗体反应。对结垢的抗体反应将是 通过两种类型的测试进行了调查。一项研究旨在确定 体液抗体对临床和微生物学的影响 当口腔的其他部位被测量时，变化可以被测量。一个 第二项研究旨在确定广泛的鳞屑或疾病 活性部位可用于增强治疗和/或微生物 回应。 对结垢的抗体反应。对结垢的抗体反应将是 通过两种类型的测试进行了调查。一项研究旨在确定 体液抗体对临床和微生物学的影响 当口腔的其他部位被测量时，变化可以被测量。一个 第二项研究旨在确定疾病的广泛规模 活性部位可用于增强治疗和/或微生物 回应。 诊断。牙周袋的电阻抗将是 结合对电子口袋的测试进行调查 深度探头以确定在检测条件中的潜在效用 口袋溃疡。计算机算法将被编写和测试以 开发方法获取有关牙周骨的定量信息 射线减影技术在最小条件下的损失 标准化，就像在常规的临床实践中发生的那样。