NOVEL THERAPIES AND DIAGNOSTICS FOR USE IN TREATMENT OF PERIDONTAL DISEASES

用于治疗牙周疾病的新疗法和诊断

• 批准号: 6104695
• 负责人: J M GOODSON
• 金额: --
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6104695
• 关键词: bone regeneration; clinical trials; computer program /software; dental disorder chemotherapy; dental disorder diagnosis; disease /disorder model; disease /disorder prevention /control; dogs; drug adverse effect; electrical impedance; glucans; human subject; human therapy evaluation; insulinlike growth factor; laboratory mouse; laboratory rat; monocyte; neutrophil; pathologic bone resorption; periodontium disorder; platelet derived growth factor; polymers; rheumatoid arthritis; technetium

It is proposed that 4 novel therapies and 2 diagnostics be evaluated. Regeneration. The potential for stimulation of periodontal regeneration with application of the polypeptide growth factors will be tested in patients who have successfully completed periodontal therapy but have residual infrabony pockets. PDGF (platelet derived growth factor) and IGF (insulin derived growth factor) will be topically applied to the tooth root and alveolar defect. The response will be evaluated by a split-mouth comparison with application of the vehicle alone. Immunomodulators. Proof of principle studies will be conducted by "piggy- back" analysis of two placebo controlled studies in which patients with systemic disease are being treated by new types of therapy. This includes an investigation of patients who are being treated with the IL-1 receptor antagonist ANTRIL to relieve rheumatoid arthritis and a second group of patients being treated by the neutrophil stimulating carbohydrate. Betafectin for bone marrow failure. In each case, a subpopulation with coincident periodontal disease will be identified and clinical measures of change following therapy evaluated. In addition, animal studies are planned to examine the effect of these agents in model systems. Antibody Response to Scaling. The antibody response to scaling will be investigated in two types of tests. One study is designed to determine if clinical and microbiological effects associated with humoral antibody changes can be measured when sites are scaled elsewhere in the mouth. A second study is designed to determine if extensive scaling or disease active sites can be used to augment therapeutic and/or microbiologic response. Antibody Response to Scaling. The antibody response to scaling will be investigated in two types of tests. One study is designed to determine if clinical and microbiological effects associated with humoral antibody changes can be measured when sites are scaled elsewhere in the mouth. A second study is designed to determine if extensive scaling of disease active sites can be used to augment therapeutic and/or microbiologic response. Diagnostic. Electrical impedance of the periodontal pocket will be investigated in conjunction with the testing of an electronic pocket depth probe to determine potential utility in detecting conditions of pocket ulceration. Computer algorithms will be written and tested to develop methods to obtain quantitative information on periodontal bone loss by radiographic subtraction techniques under conditions of minimal standardization such as would occur in routine clinical practice.

建议评价4种新疗法和2种诊断方法。 重生。刺激牙周再生的潜力 应用多肽生长因子将在 成功完成牙周治疗但 残留的骨下袋。PDGF（血小板衍生生长因子）和IGF （胰岛素衍生生长因子）将局部应用于牙齿 牙根和牙槽骨缺损。将通过裂口评价反应 与单独使用车辆相比。 免疫调节剂。原理验证研究将由"猪- 对两项安慰剂对照研究的分析， 系统性疾病正在通过新型疗法来治疗。这包括 对接受IL-1受体治疗的患者的调查 拮抗剂ANTRIL缓解类风湿性关节炎，第二组 患者接受中性粒细胞刺激碳水化合物治疗。 用倍他克丁治疗骨髓衰竭在每种情况下， 同时牙周病将确定和临床措施 评估治疗后的变化。此外，动物研究 计划在模型系统中检查这些代理的效果。 抗体对结垢的反应。抗体对结垢的反应将是 在两种类型的测试中进行了研究。一项研究旨在确定 如果与体液抗体相关的临床和微生物学效应 当在口腔中的其他部位缩放时，可以测量变化。一 第二项研究旨在确定是否广泛的鳞屑或疾病 活性位点可用于增强治疗和/或微生物活性 反应 抗体对结垢的反应。抗体对结垢的反应将是 在两种类型的测试中进行了研究。一项研究旨在确定 如果与体液抗体相关的临床和微生物学效应 当对口腔中的其他位置进行缩放时，可以测量变化。一 第二项研究的目的是确定是否广泛的疾病规模， 活性位点可用于增强治疗和/或微生物活性 反应 诊断。牙周袋的电阻抗将是 结合电子口袋的测试进行了调查 深度探测器，以确定在检测 袋状溃疡。计算机算法将被编写和测试， 开发获得牙周骨定量信息的方法 在最小条件下通过放射减影技术丢失 标准化，例如在常规临床实践中会发生的标准化。