Insulin signalling to the podocyte; pathological importance and therapeutic potential.

向足细胞发出胰岛素信号；

• 批准号: MR/K010492/1
• 负责人: Richard Coward
• 金额: $ 186.54万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK010492%2F1
• 关键词: Insulin; signalling; podocyte; pathological; importance

The number of people in the world who are developing end stage kidney failure is rapidly increasing principally due to this condition being associated with diabetes. When this occurs patients require multiple medications, together with dialysis or kidney transplantation, or they die. Discovering new ways to prevent kidney failure is therefore critical. We have discovered that a cell, called the podocyte, in the kidney is implicated in the early stages of kidney disease (before the kidney completely fails) and this cell is responsive to a hormone called insulin. It appears that this cell needs insulin to remain healthy. We now want to understand exactly how insulin signals to the podocyte and explore if increasing insulin sensitivity of the this cell can prevent the kidney from completely failing. If this is true then strategies that increase podocyte insulin sensitivity could have great therapeutic potential in preventing kidney failure and stopping patients needing dialysis or kidney transplantation.

世界上发展为终末期肾衰竭的人数正在迅速增加，主要是因为这种情况与糖尿病有关。当这种情况发生时，患者需要多种药物治疗，同时进行透析或肾移植，否则就会死亡。因此，发现预防肾衰竭的新方法至关重要。我们发现，肾脏中有一种叫做足细胞的细胞与肾脏疾病的早期阶段（在肾脏完全衰竭之前）有关，这种细胞对一种叫做胰岛素的激素有反应。看来这个细胞需要胰岛素来保持健康。我们现在想确切地了解胰岛素是如何向足细胞发出信号的，并探索增加足细胞的胰岛素敏感性是否可以防止肾脏完全衰竭。如果这是真的，那么增加足细胞胰岛素敏感性的策略可能在预防肾衰竭和停止需要透析或肾移植的患者方面具有巨大的治疗潜力。

项目成果

Insulin signaling: implications for podocyte biology in diabetic kidney disease.

• DOI: 10.1097/mnh.0000000000000078
• 发表时间: 2015-01
• 期刊: Current opinion in nephrology and hypertension
• 影响因子: 3.2
• 作者: Coward R;Fornoni A
• 通讯作者: Fornoni A

Encyclopedia of Cell Biology

细胞生物学百科全书

• DOI: 10.1016/b978-0-12-394447-4.20047-3
• 发表时间: 2016
• 作者: Giese S

Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx.

醛固酮通过基质金属蛋白酶依赖性糖蛋白糖脂诱导蛋白尿。

• DOI: 10.1016/j.kint.2018.08.024
• 发表时间: 2019-01
• 期刊: Kidney international
• 影响因子: 19.6
• 作者: Butler MJ;Ramnath R;Kadoya H;Desposito D;Riquier-Brison A;Ferguson JK;Onions KL;Ogier AS;ElHegni H;Coward RJ;Welsh GI;Foster RR;Peti-Peterdi J;Satchell SC
• 通讯作者: Satchell SC

The protective role of peroxisome proliferator-activated receptor gamma in lipotoxic podocytes.

• DOI: 10.1016/j.bbalip.2023.159329
• 发表时间: 2023-05
• 期刊: Biochimica et biophysica acta. Molecular and cell biology of lipids
• 作者: Almudena G Carrasco;Adriana Izquierdo-Lahuerta;Á. Valverde;L. Ni;Elena Flores-Salguero;R. Coward;G. Medina-Gómez

Outcome monitoring and risk stratification after cardiac procedure in neonates, infants, children and young adults born with congenital heart disease: protocol for a multicentre prospective cohort study (Children OMACp).

• DOI: 10.1136/bmjopen-2023-071629
• 发表时间: 2023-08-08
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Baquedano, Mai;de Jesus, Samantha E.;Rapetto, Filippo;Murphy, Gavin J.;Angelini, Gianni;Benedetto, Umberto;Caldas, Patricia;Srivastava, Prashant K.;Uzun, Orhan;Luyt, Karen;Corcia, Cecilia Gonzalez;Taliotis, Demetris;Stoica, Serban;Lawlor, Deborah A.;Bamber, Andrew R.;Perry, Alison;Skeffington, Katie L.;Omeje, Ikenna;Pappachan, John;Mumford, Andrew D.;Coward, Richard J. M.;Kenny, Damien;Caputo, Massimo
• 通讯作者: Caputo, Massimo