权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Identifying New Molecular Pathways and Therapeutic Targets in Diabetic Kidney Disease

确定糖尿病肾病的新分子途径和治疗靶点

基本信息

批准号：
MR/W019582/1
负责人：
Richard Coward
金额：
$ 102.34万
依托单位：
University of Bristol
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FW019582%2F1
关键词：
Identifying New Molecular Pathways Therapeutic

项目摘要

Diabetic kidney disease (DKD) is the leading cause of kidney failure in the world and increasing at alarming rates due to the diabetes-inducing lifestyles we live. Currently the treatments for DKD are inadequate and many patients develop kidney failure needing dialysis or a kidney transplant. If this happens these patients are more likely to suffer from cardiovascular problems such as heart attacks and stroke and are much more likely to die prematurely.Work by our laboratory has shown that a cell in the filtering unit of the kidney called the podocyte is important in the development of DKD and that the major hormone in diabetes, insulin, is able to beneficially signal to this cell. When podocyte-insulin signalling is lost it is detrimental to kidney function and kidney disease develops. We have developed a drug screening assay to identify new therapies that make the podocyte more insulin-sensitive and this project has identified a cell target we would like to follow up. We intend studying this target in mouse models of DKD and human podocyte cells in dishes to clarify if it might be a good treatment for patients with diabetic kidney disease in the future.

糖尿病肾病（DKD）是世界上肾衰竭的主要原因，并且由于我们生活的糖尿病诱导生活方式而以惊人的速度增长。目前DKD的治疗是不够的，许多患者发展为肾衰竭，需要透析或肾移植。如果发生这种情况，这些患者更有可能遭受心血管问题，如心脏病发作和中风，更有可能过早死亡。我们实验室的工作表明，肾脏过滤单位中的一种细胞称为足细胞在DKD的发展中很重要，糖尿病的主要激素胰岛素能够向该细胞发出有益的信号。当足细胞-胰岛素信号传导丢失时，它对肾功能有害，并发展为肾脏疾病。我们已经开发了一种药物筛选试验，以确定新的疗法，使足细胞更胰岛素敏感，这个项目已经确定了一个细胞目标，我们想跟进。我们打算在DKD小鼠模型和培养皿中的人类足细胞中研究该靶点，以阐明它是否可能在未来成为糖尿病肾病患者的良好治疗方法。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The protective role of peroxisome proliferator-activated receptor gamma in lipotoxic podocytes.

DOI：
10.1016/j.bbalip.2023.159329
发表时间：
2023-05
期刊：
Biochimica et biophysica acta. Molecular and cell biology of lipids
影响因子：
0
作者：
Almudena G Carrasco;Adriana Izquierdo-Lahuerta;Á. Valverde;L. Ni;Elena Flores-Salguero;R. Coward;G. Medina-Gómez
通讯作者：
Almudena G Carrasco;Adriana Izquierdo-Lahuerta;Á. Valverde;L. Ni;Elena Flores-Salguero;R. Coward;G. Medina-Gómez

Encyclopedia of Cell Biology

细胞生物学百科全书

DOI：
10.1016/b978-0-12-394447-4.20047-3
发表时间：
2016
期刊：
影响因子：
0
作者：
Giese S
通讯作者：
Giese S

Outcome monitoring and risk stratification after cardiac procedure in neonates, infants, children and young adults born with congenital heart disease: protocol for a multicentre prospective cohort study (Children OMACp).

DOI：
10.1136/bmjopen-2023-071629
发表时间：
2023-08-08
期刊：
BMJ OPEN
影响因子：
2.9
作者：
Baquedano, Mai;de Jesus, Samantha E.;Rapetto, Filippo;Murphy, Gavin J.;Angelini, Gianni;Benedetto, Umberto;Caldas, Patricia;Srivastava, Prashant K.;Uzun, Orhan;Luyt, Karen;Corcia, Cecilia Gonzalez;Taliotis, Demetris;Stoica, Serban;Lawlor, Deborah A.;Bamber, Andrew R.;Perry, Alison;Skeffington, Katie L.;Omeje, Ikenna;Pappachan, John;Mumford, Andrew D.;Coward, Richard J. M.;Kenny, Damien;Caputo, Massimo
通讯作者：
Caputo, Massimo

Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation.

志贺毒素靶向足细胞，通过激活内皮补体引起溶血性尿毒症综合征。