CAUSES OF VARIATION IN SECONDARY METABOLITE BY TROPICAL MARINE ORGANISMS

热带海洋生物次级代谢产物变化的原因

• 批准号: 5212156
• 负责人: VALERIE J PAUL
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5212156
• 关键词: Invertebrata; Porifera; alternatives to animals in research; animal age group; animal population study; aquatic organism; biological products; biosynthesis; coral; food chain; life cycle; lighting; physical chemical interaction; plants; saltwater environment

This research will examine the importance of biological and physical causes of variation in the production of bioactive secondary metabolites by tropical seaweeds and invertebrates. The research has important biomedical consequences since it will focus on understanding what factors affect the yields of biomedically important marine natural products. First, differences in types and concentrations of secondary metabolites in different tissues, among individuals, at different ages and life history stages, and among populations of seaweeds and invertebrates will be examined. Facultative changes in chemical defenses will be examined for seaweeds, sponges, and soft corals exposed to: 1) increased grazing by fishes, mesograzers, and specialists predators; and 2) different resource levels of light and nutrients. The proposed research will provide information on chemical variation and its causes and the ability and timing of seaweeds and invertebrates to change their allocation of chemical defenses. The study will contribute to our limited knowledge of the chemical interactions of seaweeds and marine invertebrates, the physiological properties of marine natural products, and the relationship between natural adaptive functions of secondary metabolites and their biomedical potential. Bioactive metabolites will be incorporated into established testing programs (Univ. of Hawaii, UC Santa Barbara, Wayne State University Medical School) to determine their pharmacological activities in specific assays. Funding is requested primarily for personnel and supplies to carry out this research. This research program will provide educational opportunities for minority undergraduate and graduate (M.S. degree) students at the University of Guam, a predominantly undergraduate and minority institution with relatively large biology, nursing, and public health related programs.

这项研究将研究生物学和物理的重要性 生物活性二级代谢产生生产变化的原因 由热带海藻和无脊椎动物。 这项研究很重要 生物医学后果，因为它将集中于了解哪些因素 影响生物医学重要的海洋天然产品的产量。 首先，次级代谢产物的类型和浓度差异 在不同的组织中，个人之间，不同年龄和生活 历史阶段，海藻和无脊椎动物的种群将 被检查。 将检查化学防御的兼性变化 对于海藻，海绵和软珊瑚的暴露于：1）放牧增加 由鱼类，中批和专家捕食者组成； 2）不同 资源水平的光和营养。 拟议的研究将 提供有关化学变化及其原因及其能力的信息 以及海藻和无脊椎动物的时间来改变其分配 化学防御。 这项研究将有助于我们有限的知识 海藻和海洋无脊椎动物的化学相互作用， 海洋天然产品的生理特性和关系 在次生代谢产物的自然自适应功能及其之间 生物医学潜力。 生物活性代谢物将纳入已建立的测试 计划（夏威夷大学，加州大学圣塔芭芭拉分校，韦恩州立大学 医学院）以特定的方式确定其药理活动 测定。 资金主要用于人员和用品 进行这项研究。 该研究计划将提供教育 少数族裔本科和毕业生的机会（硕士学位） 关岛大学的学生，主要是本科生 少数族裔机构具有相对较大的生物学，护理和公众 与健康相关的计划。