Sedentary Behaviour Interrupted: Acute, medium and long-term effects on biomarkers of healthy aging, physical function and mortality

久坐行为中断：对健康老龄化、身体功能和死亡率的生物标志物的急性、中期和长期影响

• 批准号: 9278020
• 负责人: Jacqueline Kerr
• 金额: $ 190.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9278020
• 关键词: Accelerometer; Acute; Address; Adopted; Adult; Age; Aging; Algorithms; American Heart Association; Behavior; Behavioral; Biological; Biological Markers; Biostatistics Core; Blood Pressure; Blood flow; Cessation of life; Chronic Disease; Classification; Computational Technique; Cross-Over Trials; Data; Devices; Disease; Dose; Educational workshop; Elderly; Emotional; Energy Metabolism; Ensure; Epidemiology; Female; Goals; Grant; Guidelines; Health; Healthcare; High Prevalence; Hour; Interruption; Intervention; Intervention Studies; Laboratories; Latina; Long-Term Effects; Machine Learning; Measurement; Measures; Metabolic; Methodology; Mitochondria; Movement; Muscle; National Institute on Aging; Outcome; Participant; Patient Self-Report; Pattern; Physical Function; Physical activity; Pilot Projects; Policies; Postmenopause; Posture; Procedures; Prospective Studies; Public Health; Randomized; Recommendation; Research; Research Design; Research Methodology; Resources; Risk; Series; Specific qualifier value; Standardization; Thigh structure; Time; Training; Walking; Woman; Women' s Health; age effect; age group; attentional control; base; behavior observation; blood glucose regulation; cognitive function; design; disability; epidemiology study; evidence base; experience; healthy aging; improved; innovation; mortality; novel; older women; programs; prospective; randomized trial; response biomarker; sedentary; sedentary lifestyle; young adult

Abstract Older adults struggle to engage in health enhancing physical activity (PA) and spend up to 11 hours a day sitting. Older women, in particular, are at increased risk of chronic disease and disability, and use a high proportion of healthcare resources. Improving both these behaviors has promise for improving several salient aging outcomes, but evidence to inform guidelines on how best to interrupt long periods of sedentary behavior (SB) are lacking. Few laboratory-based trials have included adults over 70 years old, have focused on PA to interrupt SB, and have not tested standing breaks that might be acceptable to older adults. A recent review showed that in the real world, traditional PA interventions do not meaningfully impact SB. In contrast, interventions that focus on standing can reduce SB, up to 2 hours per day. Epidemiological studies have shown associations between self-reported SB and increased risks of death and metabolic outcomes, but very few prospective studies have employed objective measures of SB. Although accelerometer measures can indicate the intensity of movement or lack of it, traditional cutpoints do not accurately classify behaviors such as sitting, standing or walking. While pilot intervention studies, using thigh worn inclinometers, have demonstrated that SB can be greatly reduced, there are no RCTs in older adults with health outcomes. There is much room for improvement in our understanding of SB and healthy aging. The National Institute on Aging conducted a summer workshop series to address this issue in 2013. We have therefore designed a Program project – Sedentary Time and Aging Research (STAR) – to provide more rigorous and comprehensive evidence on how to interrupt sitting time and the consequences for healthy aging. In particular, we are proposing a paradigm shift away from energy expenditure as the primary mechanism for health outcomes to investigating behaviors such as brief sit-to-stand transitions that expend little energy but engage muscles, improve postural blood flow, and may impact physical functioning in older adults. Further, we will study a broader range of outcomes than investigated to date, including targeted novel mechanisms important for healthy aging. The STAR program will include 3 Projects and 2 Cores for study of postmenopausal women at risk for chronic disease. STAR includes 2 randomized trials, in the laboratory (N=86) and in the real world (N=592), with focus on optimizing new computational techniques to apply to existing prospective accelerometer data (n>6000). All projects will investigate the consequences of extended sitting, standing, brief sit-to-stand transitions and PA breaks on mechanisms of healthy aging including glucose regulation, endothelial functioning, and mitochondrial functioning. We will also investigate physical functioning, blood pressure and in Project 3, 5-7 year mortality risk. All Projects will compare effects across age groups. STAR will provide a comprehensive evidence base that can inform public health guidelines on SB and aging. We will coordinate our efforts with a new American Heart Association Center on SB and Latinas.

抽象的 老年人努力从事健康增强体育锻炼（PA）并每天最多花费11个小时 坐着。尤其是老年妇女，患有慢性疾病和残疾的风险增加，并使用高 医疗资源的比例。改善这两种行为已承诺改善几种显着性 衰老的结果，但有证据以告知指南，如何最好地中断长时间的久坐行为 （SB）缺乏。很少有实验室试验包括70岁以上的成年人，专注于PA 中断SB，尚未测试老年人可能可以接受的站立断裂。最近的评论 表明，在现实世界中，传统的PA干预措施不会有意义地影响SB。相比之下， 专注于站立的干预措施可以减少SB，每天最多2个小时。流行病学研究已有 表明自我报告的SB与死亡风险增加和代谢结果之间的关联，但非常 很少有前瞻性研究对SB进行客观测量。尽管加速度计的测量可以 指标运动的强度或缺乏它的强度，传统的切口并未准确地对这样的行为进行分类 坐着，站着或走路。在使用大腿磨损督米的试点干预研究中， 证明SB可以大大减少，但在患有健康状况的老年人中没有RCT。那里 我们对SB和健康衰老的理解是很大程度上可以改善的。国家老龄研究所 进行了夏季研讨会系列，以解决2013年的这个问题。因此，我们设计了一个程序 项目 - 久坐的时间和衰老研究（Star） - 提供更严格，更全面的 有关如何中断坐姿以及健康衰老的后果的证据。特别是，我们是 提出范式从能源消耗作为健康结果的主要机制转变为 调查行为，例如短暂的静坐过渡，探索几乎没有能量但吸引肌肉的行为， 改善姿势血流，并可能影响老年人的身体功能。此外，我们将研究 比迄今为止研究的更广泛的结果范围，包括针对性的新型机制 健康衰老。 Star计划将包括3个项目和2个核心，用于研究绝经后妇女 慢性病的风险。星星包括2个随机试验，在实验室（n = 86）和现实世界中 （n = 592），重点是优化新的计算技术以适用于现有的潜在 加速度计数据（n> 6000）。所有项目都将调查延长坐着，站立，简短的后果 静止不动的过渡和PA破坏了健康衰老的机制，包括调节葡萄糖， 内皮功能和线粒体功能。我们还将调查身体功能，血液 压力和项目3，5 - 7年的死亡率风险。所有项目都将比较跨年龄段的影响。星星 将提供一个全面的证据基础，可以为SB和衰老提供通知公共卫生指南。我们将 与SB和Latinas的新美国心脏协会中心协调我们的努力。