WormBase: an evolving resource for nematode biology

WormBase：线虫生物学的不断发展的资源

• 批准号: MR/L001020/1
• 负责人: Matthew Berriman
• 金额: $ 120.16万
• 依托单位: Wellcome Sanger Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL001020%2F1
• 关键词: WormBase; evolving; resource; nematode; biology

Many developments in modern medicine are based on the enormous progress made over the last 50 years in our understanding of how our genes work. For example, drugs interact with genes to change how biological systems function. Much of the research that has led to this progress is hard or impossible to do in humans. Because all animals share evolutionary origins, study of simple animals helps to understand human biology. Certain key model organisms have been the focus of intensive study, and some of the most important progress has been made with extremely simple animals. One of these is the tiny roundworm, or nematode, Caenorhabditis elegans. C. elegans research has been strategically supported by the MRC for over 40 years, leading to two Nobel prizes in the last five years, and is a key contributor to our understanding of basic processes such as cell death and aging.In addition to its relevance for understanding animal biology, research on C. elegans is particularly important to our understanding of the biology of other nematodes. Globally, more than one billion people are infected with nematode parasites, including blood-borne filarial parasites, such as Onchocerca that causes river blindness, and Wuchereria that cause elephantiasis; as well as intestinal nematodes such as hookworms, whipworms and giant round worms. Typically infections are associated with and promote poverty. For most parasitic nematodes, maintaining full life cycles in the laboratory is either difficult or impossible and few molecular tools exist. Thus researchers are highly reliant on functional studies in C. elegans and their extrapolation (via sequence homology) into the parasites of sister taxa.Genetic research has been revolutionized by obtaining the complete DNA sequence (the genome) of the organism being studied, which contains all the gene sequences. C. elegans was the first animal to have its genome sequenced and now major programmes are collecting genome sequences for parasitic species. To use genome sequences and all the new information about genes requires information resources that tie together DNA information with experimental data, and relate corresponding genes across animals. This application will enable the support and development of WormBase, the reference information resource for all genomic and biological data for C. elegans, and its expansion to enable the curation of genomic and experimental information for increasing numbers of nematode parasites. WormBase is essential both for fundamental research that uses C. elegans as a model, and for research into nematodes that cause disease. By relating these two branches of nematode research, WormBase will be uniquely placed to enable community-wide exploitation of data emerging for parasites by applying information, experience, and technological infrastructure developed for C. elegans.

现代医学的许多发展都是基于过去50年来我们对基因工作原理的理解所取得的巨大进步。例如，药物与基因相互作用，改变生物系统的功能。导致这一进展的许多研究很难或不可能在人类身上进行。因为所有动物都有共同的进化起源，所以研究简单的动物有助于理解人类生物学。某些关键的模式生物一直是深入研究的重点，一些最重要的进展是在极其简单的动物身上取得的。其中之一是微小的蛔虫，或线虫，秀丽隐杆线虫。C.秀丽隐杆线虫的研究在过去的40年里一直受到MRC的战略支持，在过去的五年里获得了两项诺贝尔奖，并且是我们理解细胞死亡和衰老等基本过程的关键贡献者。秀丽线虫对我们理解其他线虫的生物学特性特别重要。在全球范围内，超过10亿人感染线虫寄生虫，包括血液传播的丝虫寄生虫，如导致河盲症的盘尾丝虫和导致象皮病的吴策线虫;以及肠道线虫，如钩虫，鞭虫和巨型蠕虫。感染通常与贫穷有关，并加剧贫穷。对于大多数寄生线虫，在实验室中维持完整的生命周期要么是困难的，要么是不可能的，而且几乎没有分子工具存在。因此，研究人员高度依赖于C。通过获得所研究的生物体的完整DNA序列（基因组），遗传研究已经发生了革命性的变化，其中包含了所有的基因序列。C.线虫是第一个对其基因组测序的动物，现在主要方案正在收集寄生物种的基因组序列。要使用基因组序列和所有关于基因的新信息，需要将DNA信息与实验数据联系起来的信息资源，并将动物之间的相应基因联系起来。该应用程序将支持和开发WormBase，这是所有C基因组和生物数据的参考信息资源。elegans，及其扩展，使基因组和实验信息的策展越来越多的线虫寄生虫。WormBase对于使用C语言的基础研究都是必不可少的。线虫作为模型，并用于研究引起疾病的线虫。通过将线虫研究的这两个分支联系起来，WormBase将处于独特的地位，通过应用为C.优雅的

项目成果

Comparative genomics of the major parasitic worms.

• DOI: 10.1038/s41588-018-0262-1
• 发表时间: 2019-01
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: International Helminth Genomes Consortium

Using WormBase: A Genome Biology Resource for Caenorhabditis elegans and Related Nematodes.

• DOI: 10.1007/978-1-4939-7737-6_14
• 发表时间: 2018
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Grove C;Cain S;Chen WJ;Davis P;Harris T;Howe KL;Kishore R;Lee R;Paulini M;Raciti D;Tuli MA;Van Auken K;Williams G;WormBase Consortium
• 通讯作者: WormBase Consortium

Ensembl Genomes 2018: an integrated omics infrastructure for non-vertebrate species.

• DOI: 10.1093/nar/gkx1011
• 发表时间: 2018-01-04
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Kersey PJ;Allen JE;Allot A;Barba M;Boddu S;Bolt BJ;Carvalho-Silva D;Christensen M;Davis P;Grabmueller C;Kumar N;Liu Z;Maurel T;Moore B;McDowall MD;Maheswari U;Naamati G;Newman V;Ong CK;Paulini M;Pedro H;Perry E;Russell M;Sparrow H;Tapanari E;Taylor K;Vullo A;Williams G;Zadissia A;Olson A;Stein J;Wei S;Tello-Ruiz M;Ware D;Luciani A;Potter S;Finn RD;Urban M;Hammond-Kosack KE;Bolser DM;De Silva N;Howe KL;Langridge N;Maslen G;Staines DM;Yates A
• 通讯作者: Yates A

WormBase 2017: molting into a new stage.

• DOI: 10.1093/nar/gkx998
• 发表时间: 2018-01-04
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Lee RYN;Howe KL;Harris TW;Arnaboldi V;Cain S;Chan J;Chen WJ;Davis P;Gao S;Grove C;Kishore R;Muller HM;Nakamura C;Nuin P;Paulini M;Raciti D;Rodgers F;Russell M;Schindelman G;Tuli MA;Van Auken K;Wang Q;Williams G;Wright A;Yook K;Berriman M;Kersey P;Schedl T;Stein L;Sternberg PW
• 通讯作者: Sternberg PW

WormBase 2016: expanding to enable helminth genomic research.

• DOI: 10.1093/nar/gkv1217
• 发表时间: 2016-01-04
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Howe KL;Bolt BJ;Cain S;Chan J;Chen WJ;Davis P;Done J;Down T;Gao S;Grove C;Harris TW;Kishore R;Lee R;Lomax J;Li Y;Muller HM;Nakamura C;Nuin P;Paulini M;Raciti D;Schindelman G;Stanley E;Tuli MA;Van Auken K;Wang D;Wang X;Williams G;Wright A;Yook K;Berriman M;Kersey P;Schedl T;Stein L;Sternberg PW
• 通讯作者: Sternberg PW