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Developmental and meiotic potential of oocytes derived from human ovarian germ line stem cells (OSCs) in vitro.

人卵巢生殖系干细胞 (OSC) 卵母细胞的体外发育和减数分裂潜力。

基本信息

批准号：
MR/L00299X/1
负责人：
Evelyn Telfer
金额：
$ 25.79万
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FL00299X%2F1
关键词：
Developmental meiotic potential oocytes derived

项目摘要

For decades, scientists have believed that women were born with all the eggs they would ever have and that no new ones could ever be made. Recently a group of researchers in the USA isolated a primitive "stem" like cell from the ovaries of adult women. These cells were shown to be capable of forming what appeared to be new eggs (oocytes) when they were injected back into ovarian tissue. The implications of this are potentially enormous, but at the moment we know very little about what these cells may or may not be capable of. If we could make new eggs we could eventually help restore fertility in women who have become infertile for a variety of reasons, including chemotherapy, early menopause or just normal ageing. However, these findings have led to controversy and many questions remain as to whether these new eggs can develop normally. This project will determine whether these cells can be isolated from the ovaries of healthy women from a range of ages. Then using a system which we have developed where we can grow eggs outside the body (culture system), we will determine whether these cells can form new eggs and whether they are normal. The ultimate end point of this work would be to determine whether these cells were capable of forming eggs that could be fertilised and form embryos.

几十年来，科学家们一直认为，女性出生时就已经拥有了所有的卵子，而且永远不会产生新的卵子。最近，美国的一组研究人员从成年女性的卵巢中分离出了一种原始的“干”样细胞。当这些细胞被注射回卵巢组织时，它们被证明能够形成新的卵子（卵母细胞）。这可能会产生巨大的影响，但目前我们对这些细胞可能具有或不具有的能力知之甚少。如果我们能够制造新的卵子，我们最终可以帮助那些因各种原因而不孕的妇女恢复生育能力，包括化疗，更年期提前或正常衰老。然而，这些发现引起了争议，关于这些新卵子是否能正常发育的问题仍然存在许多问题。该项目将确定这些细胞是否可以从不同年龄的健康女性的卵巢中分离出来。然后使用我们开发的一种可以在体外培养卵子的系统（培养系统），我们将确定这些细胞是否可以形成新的卵子，以及它们是否正常。这项工作的最终目的是确定这些细胞是否能够形成可以受精并形成胚胎的卵子。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Replenishing the adult ovarian follicle population: a fresh look at dogma.

DOI：
10.1093/molehr/gaw017
发表时间：
2016-05
期刊：
Molecular human reproduction
影响因子：
4
作者：
R. Anderson;E. Telfer
通讯作者：
R. Anderson;E. Telfer

Initial characterisation of adult human ovarian cell populations isolated by DDX4 expression and aldehyde dehydrogenase activity.

DOI：
10.1038/s41598-018-25116-1
发表时间：
2018-05-03
期刊：
Scientific reports
影响因子：
4.6
作者：
Clarkson YL;McLaughlin M;Waterfall M;Dunlop CE;Skehel PA;Anderson RA;Telfer EE
通讯作者：
Telfer EE

Being a good egg in the 21st century.

在21世纪成为一个好鸡蛋。