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IL-12 GENE THERAPY USING DIRECT INFECTION OF TUMORS

IL-12 GENE THERAPY USING DIRECT INFECTION OF TUMORS
使用肿瘤直接感染的 IL-12 基因治疗
批准号：
5218426
负责人：
HIDEAKI TAHARA
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5218426
关键词：
breast neoplasms clinical research clinical trial phase I cytokine dosage drug screening /evaluation fibroblasts gene therapy head /neck neoplasm human subject human therapy evaluation immunomodulators melanoma mycosis fungoides lymphoma neoplasm /cancer immunology neoplasm /cancer immunotherapy

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中文摘要
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英文摘要
This Phase I, II study is to define the local and systemic toxicity and immunomodulatory effects associated with peritumoral injections of fibroblasts genetically engineered to secrete IL-12 and evaluate the clinical efficacy of this procedure. A total of 18 patients with cutaneous cancer lesions of 4 types of cancer (melanoma, breast cancer, head & neck cancer and cutaneous T-cell lymphoma) will be enrolled in the preliminary study of this maximum tolerable or "possible" dosage study.
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会议论文
PH II IL 12 GENE THERAPY MELANOMA INJECTION OF TUMORS WITH AUTO FIBROBLAST
IL 12 GENE THERAPY HEAD/NECK CANCER TUMORS W/ AUTOLOGOUS FIBROBLASTS
PH II IL 12 GENE THERAPY MELANOMA INJECTION OF TUMORS WITH AUTO FIBROBLAST
CANCER GENE THERAPY IN MURINE MODELS USING CELLULAR IL-10--VECTORS/AUTOIMMUNITY
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