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IL-12 GENE THERAPY USING DIRECT INJECTION OF TUMORS

IL-12 GENE THERAPY USING DIRECT INJECTION OF TUMORS
使用肿瘤直接注射进行 IL-12 基因治疗
批准号：
6245641
负责人：
HIDEAKI TAHARA
金额：
$1.76万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-03-18 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6245641
关键词：
breast neoplasms clinical research clinical trial phase I dosage fibroblasts gene therapy head /neck neoplasm human subject human therapy evaluation immunomodulators interleukin 12 melanoma mycosis fungoides lymphoma neoplasm /cancer immunotherapy

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中文摘要
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英文摘要
The objective of this phase I,II study is to define the local & systemic toxicity & immunmodulatory effects associated with peritumoral injections of fibroblasts genetically engineered to secrete IL-12 & evaluate the clinical efficacy of this procedure. A total of 18 patients with cutaneous cancer lesions of 4 types of cancer (melanoma, breast cancer, head and neck cancer and cutaneous T-cell lymphoma) will be enrolled in the preliminary study of this maximum tolerable or "possible" dosage study.
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会议论文
PH II IL 12 GENE THERAPY MELANOMA INJECTION OF TUMORS WITH AUTO FIBROBLAST
IL 12 GENE THERAPY HEAD/NECK CANCER TUMORS W/ AUTOLOGOUS FIBROBLASTS
PH II IL 12 GENE THERAPY MELANOMA INJECTION OF TUMORS WITH AUTO FIBROBLAST
IL 12 GENE THERAPY HEAD/NECK CANCER TUMORS W/ AUTOLOGOUS FIBROBLASTS
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