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IL 12 GENE THERAPY USING INJECTION OF TUMORS W/GENETICALLY ENGINEERED FIBROBLAST

IL 12 GENE THERAPY USING INJECTION OF TUMORS W/GENETICALLY ENGINEERED FIBROBLAST
使用基因工程成纤维细胞注射肿瘤进行 IL 12 基因治疗
批准号：
6275779
负责人：
HIDEAKI TAHARA
金额：
$1.91万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275779
关键词：
breast neoplasms clinical research clinical trial phase I dosage fibroblasts gene therapy genetic manipulation head /neck neoplasm human subject human therapy evaluation immunomodulators interleukin 12 melanoma mycosis fungoides lymphoma neoplasm /cancer immunotherapy

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中文摘要
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英文摘要
The objective of this phase I, II study is to define the local and systemic toxicity and immunmodulatory effects associated with peritumoral injections of fibroblasts genetically engineered to secrete IL-12 and evaluate the clinical efficacy of this procedure. A total of 18 patients with cutaneous cancer lesions of 4 types of cancer (melanoma, breast cancer, head and neck cancer and cutaneous T-cell lymphoma) will be enrolled in the preliminary study of this maximum tolerable or "possible" dosage study.
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