PILOT STUDY TO EVALUATE SAFETY & TOLERABILITY OF LOSARTAN W/ENALAPRIL

评估安全性的试点研究

• 批准号: 5218692
• 负责人: EDWARD M GILBERT
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5218692
• 关键词: ACE inhibitors; antihypertensive agents; clinical research; combination chemotherapy; drug administration rate /duration; drug screening /evaluation; drug tolerance; enalapril; exercise; heart disorder chemotherapy; heart failure; human subject; human therapy evaluation; neurohormones; quality of life

This study investigates the safety and tolerability of losartan administered concurrently with the usual dose (10mg BID) of enalapril in patients with NYHA Functional Class III to IV heart failure treated previously with an ACE inhibitor. Additionally, to investigate the effects of the three treatment regimens of losartan administered in addition to usual dose enalapril and high dose enalapril on submaximal exercise tolerance, neurohormone activation and quality of life.

这项研究调查了劳萨坦的安全性和耐受性 同时与依那普利的常规剂量（10mg bid）同时管理 NYHA功能性III级至IV心力衰竭的患者接受治疗 以前使用ACE抑制剂。 另外，调查 氯沙坦的三种治疗方案的影响 除通常的剂量依那倍lil和高剂量依那倍lil 运动耐受性，神经激活和生活质量。