PILOT STUDY TO EVALUATE SAFETY & TOLERABILITY OF LOSARTAN W/ENALAPRIL

本研究考察了氯沙坦的安全性和耐受性。 与常规剂量的依那普利(10 mg，2次)同时服用 NYHA功能III级至IV级心力衰竭患者 先前用血管紧张素转换酶抑制剂治疗。此外，为了调查 氯沙坦三种治疗方案治疗慢性阻塞性肺疾病的疗效观察 加用常规剂量依那普利和大剂量依那普利治疗亚极量 运动耐量、神经激素激活和生活质量。

This study investigates the safety and tolerability of losartan administered concurrently with the usual dose (10mg BID) of enalapril in patients with with NYHA Functional Class III to IV heart failure treated previously with an ACE inhibitor. Additionally, to investigate the effects of the three treatment regimens of losartan administered in addition to usual dose enalapril and high dose enalapril on submaximal exercise tolerance, neurohormone activation and quality of life.