EFFECT OF CUTANEOUS MICROANGIOPATHY ON HEALING RATES OF DIABETIC FOOT ULCERS

皮肤微血管病变对糖尿病足溃疡愈合率的影响

• 批准号: 5218970
• 负责人: LISA NEWMAN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5218970
• 关键词: antibiotics; clinical research; diabetic angiopathy; human subject; human therapy evaluation; leukocyte count; microcirculation; osteomyelitis; ulcer; wound healing

This protocol seeks to study the hypothesis that local leukocyte infiltration, even in a low-grade, clinically unsuspected osteomyelitis, may further impede the microcirculation, and that resolution of this infection with antibiotic therapy will improve microcirculatory flow. The long-term aim is to find interventions that will improve microangiopathy and accelerate ulcer healing to lower the alarming rate of amputations in diabetic limbs.

该方案旨在研究局部白细胞的假设 即使在低级，临床上未置的骨髓炎中，浸润也 可能进一步阻碍了微循环，并解决了这一点 抗生素治疗的感染将改善微循环流。 长期的目标是寻找可以改善的干预措施 微血管病和加速溃疡愈合以降低令人震惊的速度 糖尿病四肢的截肢。