MRI Detection of Skeletal Muscle Microvascular Dysfunction

骨骼肌微血管功能障碍的MRI检测

• 批准号: 7187699
• 负责人: BRUCE M. DAMON
• 金额: $ 18.91万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7187699
• 关键词: bioimaging /biomedical imaging; blood flow measurement; blood volume; cardiovascular disorder diagnosis; cardiovascular function; clinical research; diabetic angiopathy; hemodynamics; human subject; magnetic resonance imaging; medical complication; microcirculation; noninsulin dependent diabetes mellitus; noninvasive diagnosis; oxygen transport; patient oriented research; striated muscles; technology /technique development; vasomotion

DESCRIPTION (provided by applicant): The long-term complications of Type 2 Diabetes Mellitus (T2DM) include structural and functional impairments to the microvasculature. In skeletal muscle, these result in reduced blood flow for glucose disposal and to support physical activity, imperiling both local tissue and overall health. However, there are no non-invasive methods for specifically studying skeletal muscle microvascular function used in routine clinical practice. The overall objective of the proposed studies is to develop proton density- and blood oxygenation level-dependent (BOLD)- sensitive magnetic resonance imaging (MRI) techniques for studying skeletal muscle microvascular function non-invasively. Specific Aim 1 is to test the hypothesis that analysis of post-isometric contraction changes in proton density-weighted MRI signals will reproducibly and reliably distinguish between T2DM patients with microvascular disease and healthy subjects. We currently use short- and long- gradient echo MRI signals to follow blood volume and oxygenation changes following brief maximal isometric contractions. We have adapted our current protocols so as to provide greater sensitivity to the attenuated total blood flow responses and delayed blood flow kinetics in T2DM. Specific Aim 2 is to use post-contraction changes in proton density-weighted MRI signal transients to assess microvascular function in T2DM patients after initial diagnosis and during 3 months of clinical intervention according to current standards-of-care. This will allow us to examine the feasibility of using these measures to assess microvascular responses to improved glycemic control without interfering with patient care. Successfully accomplishing these aims will improve the health of persons with T2DM by providing new non-invasive techniques for assessing peripheral microvascular function. Type 2 diabetes is a serious disorder in which the body can not regulate blood sugar levels properly. One of the long-term complications of Type 2 diabetes is reduced blood flow to the muscles. This leads to even worse blood sugar control and possibly to very serious complications such as limb amputation. In these studies we will be developing new methods for studying blood flow to muscles non-invasively.

描述（由申请人提供）：2型糖尿病（T2DM）的长期并发症包括微脉管系统的结构和功能障碍。在骨骼肌中，这些导致血液流量减少，以减少葡萄糖处置并支持体育活动，从而损害局部组织和整体健康。但是，没有非侵入性方法可以专门研究常规临床实践中使用的骨骼肌微血管功能。拟议的研究的总体目的是开发质子密度和血氧水平依赖性（BOLD） - 灵敏的磁共振成像（MRI）技术，用于研究骨骼肌微血管功能。具体目的1是测试以下假设：质子密度加权MRI信号的静电后收缩变化的分析将可重复地可靠地区分有微血管疾病的T2DM患者和健康受试者。目前，我们使用短梯度回声MRI信号跟随血液体积和氧合变化，此后短暂的最大等距收缩。我们已经调整了当前的方案，以便对T2DM中的总血流反应和延迟血流动力学提供更大的敏感性。具体目的2是使用质子密度加权MRI信号瞬变的共抗拉后变化，以评估初始诊断后的T2DM患者的微血管功能，并根据当前护理标准在临床干预的3个月内进行微血管功能。这将使我们能够检查使用这些措施来评估对改善血糖控制的微血管反应的可行性，而不会干扰患者护理。成功实现这些目标将通过提供新的非侵入性技术来评估周围微血管功能，从而改善T2DM患者的健康状况。 2型糖尿病是一种严重的疾病，人体无法正确调节血糖水平。 2型糖尿病的长期并发症之一是减少了流向肌肉的血液。这会导致更严重的血糖控制，并可能导致非常严重的并发症，例如肢体截肢。在这些研究中，我们将开发新的方法，用于非侵入性地研究肌肉。