EFFECT OF CUTANEOUS MICROANGIOPATHY ON HEALING RATES OF DIABETIC FOOT ULCERS

皮肤微血管病变对糖尿病足溃疡愈合率的影响

• 批准号: 6246252
• 负责人: LISA NEWMAN
• 金额: $ 4.47万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-12 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246252
• 关键词: antibiotics; clinical research; diabetic angiopathy; human subject; human therapy evaluation; leukocyte count; microcirculation; osteomyelitis; ulcer; wound healing

This protocol seeks to study the hypothesis that local leukocyte infiltration, even in a low-grade, clinically unsuspected osteomyelitis, may further impede the microcirculation, and that resolution of this infection with antibiotic therapy will improve microcirculatory flow. The long-term aim is to find inter-ventions that will improve microangiopathy and accelerate ulcer healing to lower the alarming rate of amputations in diabetic limbs.

该方案旨在研究局部白细胞的假设 即使在低级，临床上未置的骨髓炎中，浸润也 可能进一步阻碍了微循环，并解决了这一点 抗生素治疗的感染将改善微循环流。 这 长期的目的是找到可以改善微型病变的元素 并加速溃疡愈合，以降低截肢的截肢率 糖尿病四肢。