Excessive drinking and alcohol related harms in Adulthood: ALSPAC at 24

成年期过度饮酒和与酒精相关的危害：ALSPAC 24 岁

• 批准号: MR/L022206/1
• 负责人: Matthew Hickman
• 金额: $ 175.65万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL022206%2F1
• 关键词: Excessive; drinking; alcohol; related; harms

Reducing harm caused by alcohol is a key public health and policy priority. Liver disease deaths have increases over 4-fold in last 40 years. Over 1 in 3 young adults, both women and men, aged 20-24 drink excessively. These adverse patterns of drinking can originate in adolescence - with 50% of adolescents reporting binge drinking by aged 16. Several key alcohol related harms emerge in young adulthood, while others may persist into adulthood because of continued excessive drinking. The evidence on the relationship between patterns of excessive drinking and these key harms, especially how important early onset excessive drinking in adolescence is, needs to be strengthened. We aim to provide evidence on the proportion of young people who show signs of liver fibrosis/damage and the risk conferred by different patterns of alcohol use; the risk of poor cognitive and emotional processing associated with binge drinking; whether harmful alcohol use leads to depression in young adults; whether excessive alcohol use prevents people "maturing" out of antisocial behaviour; and amount of injury in young people associated with adverse patterns of alcohol use. In addition, harmful alcohol use or alcohol dependence also emerges in young adulthood. Further evidence is required on the relative contribution of different pathways to alcohol dependence. We plan to focus on three key pathways: the role of early behavioural or conduct problems; the impact of depressed mood and anxiety in early life and adolescence; and the potential effect of physiological response to alcohol (assessed in terms of the average amount of alcohol it takes to elicit an effect).Longitudinal data - which measures alcohol use over time, and social, environmental factors before and during alcohol use - are required to assess both of these issues - the influence of types of alcohol consumption on harm in young adulthood and pathways to problem alcohol use in young adulthood. The ALSPAC birth cohort (Children of the 90s) is the most extensively followed birth cohort in the world with detailed biological and behavioural data from before birth to late adolescence and early adulthood. We propose to take the unique opportunity provided by ALSPAC to measure alcohol related harms and outcomes in 5000 young people aged 24/25. Testing the robustness and strength of the association between alcohol and harm or the importance of different pathways to alcohol dependence will be important. Two key problems are confounding (where an association maybe explained by another factor) and missing data (which is higher in people from lower socio-economic groups with the greater early behavioural problems). We will utilize a range of sophisticated statistical techniques that seek to address these problems, including the use where possible of genetic markers of alcohol consumption (which are unrelated to other factors) and can strengthen evidence on causation. We are a multi-disciplinary team including leading experts in methodology, alcohol and related harms. The evidence we gather and data we collect will be beneficial to other academics working in the field, and critically to public and patient groups, clinicians and policy-makers with an interest in preventing alcohol related harm.

减少酒精造成的伤害是一个关键的公共卫生和政策优先事项。在过去的40年里，肝病死亡人数增加了4倍以上。超过三分之一的年轻人，包括女性和男性，年龄在20-24岁之间。这些不良的饮酒模式可能起源于青少年-50%的青少年在16岁之前报告酗酒。几个关键的酒精相关的伤害出现在年轻的成年人，而其他人可能会持续到成年，因为持续过量饮酒。关于过度饮酒模式与这些关键危害之间关系的证据，特别是青少年早期过度饮酒的重要性，需要加强。我们的目标是提供以下方面的证据：表现出肝纤维化/损伤迹象的年轻人的比例，以及不同饮酒模式带来的风险;与酗酒相关的认知和情感处理不良的风险;有害的饮酒是否会导致年轻人抑郁;过度饮酒是否会阻止人们从反社会行为中“成熟”出来;以及与不良饮酒模式相关的年轻人受伤的数量。此外，有害的酒精使用或酒精依赖也出现在年轻的成年人。关于不同途径对酒精依赖的相对作用，需要进一步的证据。我们计划集中在三个关键途径：早期行为或行为问题的作用;抑郁情绪和焦虑在早期生活和青春期的影响;以及对酒精的生理反应的潜在影响（根据引起效果所需的平均酒精量进行评估）。纵向数据-测量酒精使用随时间的变化，以及社会，在评估这两个问题时，需要考虑饮酒前和饮酒期间的环境因素-饮酒类型对青年期危害的影响以及青年期问题饮酒的途径。ALSPAC出生队列（90年代儿童）是世界上最广泛跟踪的出生队列，提供了从出生前到青春期后期和成年早期的详细生物和行为数据。我们建议利用ALSPAC提供的独特机会，在5000名24/25岁的年轻人中测量酒精相关的危害和结果。测试酒精和伤害之间的关联的鲁棒性和强度或酒精依赖的不同途径的重要性将是重要的。两个关键问题是混淆（其中一种关联可能由另一种因素解释）和缺失数据（来自较低社会经济群体的人具有更大的早期行为问题）。我们将利用一系列复杂的统计技术来解决这些问题，包括尽可能使用酒精消费的遗传标记（与其他因素无关），并可以加强因果关系的证据。我们是一个多学科团队，包括方法学，酒精和相关危害方面的领先专家。我们收集的证据和数据将有利于在该领域工作的其他学者，并对公众和患者团体，临床医生和政策制定者有兴趣预防酒精相关伤害。

项目成果

Transdiagnostic inflammatory subgroups among psychiatric disorders and their relevance to role functioning: a nested case-control study of the ALSPAC cohort.

精神疾病之间的转诊性炎症亚组及其与角色功能的相关性：ALSPAC队列的嵌套病例对照研究。

• DOI: 10.1038/s41398-022-02142-2
• 发表时间: 2022-09-09
• 期刊: TRANSLATIONAL PSYCHIATRY
• 影响因子: 6.8
• 作者: Byrne, Jonah F.;Healy, Colm;Mongan, David;Susai, Subash Raj;Zammit, Stan;Focking, Melanie;Cannon, Mary;Cotter, David R.
• 通讯作者: Cotter, David R.

Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults.

来自印度儿童、青少年和年轻人的多中心队列的风险聚类和精神病理学。

• DOI: 10.1017/s0954579422000050
• 发表时间: 2023
• 期刊: Development and psychopathology
• 影响因子: 3.3
• 作者: Basu D

Protocol for a national monthly survey of alcohol use in England with 6-month follow-up: 'the Alcohol Toolkit Study'.

• DOI: 10.1186/s12889-015-1542-7
• 发表时间: 2015-03-07
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Beard E;Brown J;West R;Acton C;Brennan A;Drummond C;Hickman M;Holmes J;Kaner E;Lock K;Walmsley M;Michie S
• 通讯作者: Michie S

Association of maternal pre-pregnancy BMI and breastfeeding with NAFLD in young adults: a parental negative control study.

• DOI: 10.1016/j.lanepe.2021.100206
• 发表时间: 2021-11
• 期刊: The Lancet regional health. Europe
• 作者: Abeysekera KW;Orr JG;Madley-Dowd P;Fernandes GS;Zuccolo L;Gordon FH;Lawlor DA;Heron J;Hickman M
• 通讯作者: Hickman M

Comparison of brief interventions in primary care on smoking and excessive alcohol consumption: a population survey in England.

• DOI: 10.3399/bjgp16x683149
• 发表时间: 2016-01
• 期刊: The British journal of general practice : the journal of the Royal College of General Practitioners
• 作者: Brown J;West R;Angus C;Beard E;Brennan A;Drummond C;Hickman M;Holmes J;Kaner E;Michie S
• 通讯作者: Michie S