ALSPAC and Adolescent Substance Use Trajectories: Consolidation of a UK research resource

英国青少年和年轻人的药物滥用和依赖是欧洲最高的。物质使用，虽然通常在青春期开始，是异质的，可能遵循不同的模式或轨迹在不同的人。这很重要，因为药物使用的具体轨迹可能有不同的原因，可能更有可能导致青少年和成人的不良后果。如果将青少年药物使用作为单一的平均衡量标准，这些特征和模式可能会被忽略。因此，对这一领域的研究需要确定物质使用轨迹的共同类型，以便测试和探索有关其原因的具体研究问题，或预防活动可能受益或需要针对谁。这也将需要关于早期生活的详细信息，在物质使用之前，以及关于物质使用在青春期如何发展的信息。雅芳父母与儿童纵向研究（ALSPAC）对13000名儿童进行了研究，是世界上拥有此类信息的最大的出生队列。自10岁起定期评估自我报告的物质使用情况（烟草、酒精、大麻和其他非法药物）。此外，在15岁和17岁时通过头发和尿液筛查收集物质使用的生物学测量，并从3000名受试者的全基因组扫描中获得信息。我们的目标是将收集到的关于物质使用和潜在风险因素的数据结合起来，以便创建一个可访问的研究资源。我们的目标是确定并提供青少年药物使用的不同轨迹；将自我报告的数据与毒理学证据进行比较和验证；创建一个可访问的自我报告物质使用数据库，并确定在ALSPAC中收集的可能涉及增加或减少物质使用风险的所有关键措施；并对有和没有不同物质使用轨迹的人的全基因组扫描进行初步比较，以确定潜在的遗传位点，供进一步研究。

Substance misuse and dependence among adolescents and young people in the UK is among the highest in Europe. Substance use, though typically initiated in adolescence, is heterogeneous and likely to follow different patterns or trajectories among different people. This matters because specific trajectories of substance use may have a different range of causes and maybe more likely to lead to poor adolescent and adult outcomes. These characteristics and patterns maybe missed if adolescent substance use is treated as a single average measure. Research, therefore, into this area needs to identify the common types of substance use trajectory in order then to test and explore specific research questions concerning their cause, or who may benefit or needs to be targeted by prevention activities. This also will require detailed information on early life, before substance use, as well as information on how substance use develops during adolescence. The Avon Longitudinal Study of Parents and Children (ALSPAC) of 13,000 children is the largest birth cohort with such information in the world, with participants? self-reported substance use (tobacco, alcohol, cannabis and other illicit drugs) assessed regularly since the age of ten. In addition, biological measures of substance use through hair and urine screens were collected at age 15 and 17, and information from a genomewide scan is available on 3000 subjects. We aim to bring the data collected on substance use and potential risk factors together in order to create an accessible research resource. We aim to identify and make available the different trajectories of adolescent substance use; compare and validate self-reported data with toxicological evidence; create an accessible database of self-reported substance use and identify all the key measures that have been collected in ALSPAC that may be involved in increasing or decreasing the risk of substance use; and conduct preliminary comparisons of whole genome scans of people with and without different substance use trajectories to identify potential genetic sites for further investigation.