MRC Brain Banks: Joint Application to Underpin Neuroscience Research

MRC 脑库：联合应用支持神经科学研究

• 批准号: MR/L022656/1
• 负责人: Olaf Ansorge
• 金额: $ 178.74万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL022656%2F1
• 关键词: MRC; Brain; Banks; Joint; Application

This application plans to support research into the causes and potential treatment of a range of diseases affecting thebrain, some of which have been identified as priorities for research, such as dementia. The UK has a network ofestablished Brain Banks that provide human tissue samples to a wide range of researchers. Human tissue samples haveallowed a better understanding of the mechanisms operating in these complex disorders and have already aided thedevelopment of treatments for Alzheimer's disease and Parkinson's disease.This application will support four Brain Banks in Edinburgh, London, Newcastle and Oxford. These banks each have areasof particular interest, Parkinson's disease, Alzheimer's disease and motor neurone disease. However, in addition to thecollection of tissues samples from patients with brain disorders, it is also essential to collect normal tissue samples for useas controls in research. Two of the Banks have a major focus in this area, so this application will support the collection ofboth disease and normal tissue samples.The banks will support scientific research by providing human tissue samples in an efficient and cost effective manner,while ensuring the samples provided are of the high quality required by researchers. The banks have worked to improvetheir efficiency, reducing the time required to provide the samples to researchers. Details of the samples available in eachof the banks are included in a database, which is accessible through the internet. This allows researchers to see whatsamples are available and how to request these samples for their research in an easy way that will save time and speed upprogress.All four Brain Banks in this application have approval form an Ethics Committee, to ensure that their working practices meetnationally agreed standards that apply to work with human tissue samples. The work of each Bank is overseen by a localsteering committee that includes members of the public and ethics experts as well as scientists and pathologists. BrainBanking is expensive, but the operating costs of these four banks are far less than their equivalents in Europe and in theUSA.The challenges of developing treatments for complex diseases such as Alzheimer's disease and Parkinson's disease areconsiderable, but the Brain Banks in this application will play an important role in underpinning the scientific research inthese national priority areas.

这项申请计划支持对影响大脑的一系列疾病的病因和潜在治疗方法的研究，其中一些疾病已被确定为研究的优先事项，如痴呆症。英国有一个已建立的脑库网络，为广泛的研究人员提供人体组织样本。人类组织样本使我们能够更好地理解这些复杂疾病的机制，并帮助开发阿尔茨海默病和帕金森病的治疗方法。这项应用将支持爱丁堡、伦敦、纽卡斯尔和牛津的四个脑库。这些数据库中的每一个都有特别感兴趣的领域，帕金森病，阿尔茨海默病和运动神经元疾病。然而，除了从脑部疾病患者中收集组织样本外，还必须收集正常组织样本作为研究中的对照。其中两个样本库主要专注于这一领域，因此该应用程序将支持疾病和正常组织样本的收集。这两个样本库将通过以高效和成本效益的方式提供人体组织样本来支持科学研究，同时确保所提供的样本符合研究人员的高质量要求。银行已经努力提高效率，减少向研究人员提供样本所需的时间。每个样本库中的样本详细信息都包含在一个数据库中，可通过互联网访问。这使得研究人员可以看到什么样的样本是可用的，以及如何以一种简单的方式要求这些样本用于他们的研究，这将节省时间并加快进度。在这个应用程序中的所有四个脑库都得到了伦理委员会的批准，以确保他们的工作实践符合适用于人体组织样本工作的国家认可标准。每个银行的工作都由当地的指导委员会监督，该委员会包括公众和伦理专家以及科学家和病理学家。脑银行是昂贵的，但这四个银行的运营成本远远低于欧洲和美国的同类银行。开发阿尔茨海默病和帕金森病等复杂疾病的治疗方法的挑战是相当大的，但脑银行在这一应用中将在支持这些国家优先领域的科学研究方面发挥重要作用。

项目成果

Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia.

• DOI: 10.3233/jad-160946
• 发表时间: 2017
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Alghamdi A;Vallortigara J;Howlett DR;Broadstock M;Hortobágyi T;Ballard C;Thomas AJ;O'Brien JT;Aarsland D;Attems J;Francis PT;Whitfield DR
• 通讯作者: Whitfield DR