MRC Brain Banks: Joint Application to Underpin Neuroscience Research

MRC 脑库：联合应用支持神经科学研究

• 批准号: MR/L016400/1
• 负责人: Colin Smith
• 金额: $ 254.59万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL016400%2F1
• 关键词: MRC; Brain; Banks; Joint; Application

This application plans to support research into the causes and potential treatment of a range of diseases affecting thebrain, some of which have been identified as priorities for research, such as dementia. The UK has a network ofestablished Brain Banks that provide human tissue samples to a wide range of researchers. Human tissue samples haveallowed a better understanding of the mechanisms operating in these complex disorders and have already aided thedevelopment of treatments for Alzheimer's disease and Parkinson's disease.This application will support four Brain Banks in Edinburgh, London, Newcastle and Oxford. These banks each have areasof particular interest, Parkinson's disease, Alzheimer's disease and motor neurone disease. However, in addition to thecollection of tissues samples from patients with brain disorders, it is also essential to collect normal tissue samples for useas controls in research. Two of the Banks have a major focus in this area, so this application will support the collection ofboth disease and normal tissue samples.The banks will support scientific research by providing human tissue samples in an efficient and cost effective manner,while ensuring the samples provided are of the high quality required by researchers. The banks have worked to improvetheir efficiency, reducing the time required to provide the samples to researchers. Details of the samples available in eachof the banks are included in a database, which is accessible through the internet. This allows researchers to see whatsamples are available and how to request these samples for their research in an easy way that will save time and speed upprogress.All four Brain Banks in this application have approval form an Ethics Committee, to ensure that their working practices meetnationally agreed standards that apply to work with human tissue samples. The work of each Bank is overseen by a localsteering committee that includes members of the public and ethics experts as well as scientists and pathologists. BrainBanking is expensive, but the operating costs of these four banks are far less than their equivalents in Europe and in theUSA.The challenges of developing treatments for complex diseases such as Alzheimer's disease and Parkinson's disease areconsiderable, but the Brain Banks in this application will play an important role in underpinning the scientific research in these national priority areas.

该应用程序计划支持对一系列影响大脑的疾病的原因和潜在治疗的研究，其中一些已被确定为研究的重点，如痴呆症。英国有一个已建立的脑库网络，为广泛的研究人员提供人体组织样本。人体组织样本可以让我们更好地了解这些复杂疾病的运作机制，并已经帮助开发了阿尔茨海默病和帕金森病的治疗方法。该应用程序将支持爱丁堡、伦敦、纽卡斯尔和牛津的四家脑库。这些银行都有特别感兴趣的领域，帕金森病，阿尔茨海默病和运动神经元疾病。然而，除了收集脑部疾病患者的组织样本外，在研究中收集正常组织样本作为对照组也是必不可少的。其中两家银行主要关注这一领域，因此该应用程序将支持疾病和正常组织样本的收集。这些样本库将支持科学研究，以高效和经济的方式提供人体组织样本，同时确保提供的样本具有研究人员所需的高质量。这些银行一直在努力提高效率，减少向研究人员提供样本所需的时间。每个银行提供的样本的详细信息都包含在一个数据库中，可通过互联网访问。这使研究人员能够看到可用的样品以及如何以一种简单的方式请求这些样品用于他们的研究，从而节省时间并加快进展。本申请中的所有四家脑库都获得了伦理委员会的批准，以确保他们的工作实践符合适用于人体组织样本的国家商定标准。每个银行的工作都由一个地方指导委员会监督，该委员会成员包括公众和伦理专家以及科学家和病理学家。脑库是昂贵的，但这四家银行的运营成本远低于欧洲和美国的同类银行。开发诸如阿尔茨海默病和帕金森病等复杂疾病的治疗方法的挑战是相当大的，但是脑库在这方面的应用将在支持这些国家优先领域的科学研究方面发挥重要作用。

项目成果

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration

C9orf72 -ALS iPSC 衍生小胶质细胞中自噬破坏驱动的细胞自主免疫功能障碍导致神经退行性变

• DOI: 10.1101/2022.05.12.491675
• 发表时间: 2022
• 作者: Banerjee P

Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline.

• DOI: 10.1177/0271678x221077766
• 发表时间: 2022-07
• 期刊: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
• 作者: Alfieri A;Koudelka J;Li M;Scheffer S;Duncombe J;Caporali A;Kalaria RN;Smith C;Shah AM;Horsburgh K
• 通讯作者: Horsburgh K

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

• DOI: 10.1038/nn.4398
• 发表时间: 2016-12
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Adams HH;Hibar DP;Chouraki V;Stein JL;Nyquist PA;Rentería ME;Trompet S;Arias-Vasquez A;Seshadri S;Desrivières S;Beecham AH;Jahanshad N;Wittfeld K;Van der Lee SJ;Abramovic L;Alhusaini S;Amin N;Andersson M;Arfanakis K;Aribisala BS;Armstrong NJ;Athanasiu L;Axelsson T;Beiser A;Bernard M;Bis JC;Blanken LM;Blanton SH;Bohlken MM;Boks MP;Bralten J;Brickman AM;Carmichael O;Chakravarty MM;Chauhan G;Chen Q;Ching CR;Cuellar-Partida G;Braber AD;Doan NT;Ehrlich S;Filippi I;Ge T;Giddaluru S;Goldman AL;Gottesman RF;Greven CU;Grimm O;Griswold ME;Guadalupe T;Hass J;Haukvik UK;Hilal S;Hofer E;Hoehn D;Holmes AJ;Hoogman M;Janowitz D;Jia T;Kasperaviciute D;Kim S;Klein M;Kraemer B;Lee PH;Liao J;Liewald DC;Lopez LM;Luciano M;Macare C;Marquand A;Matarin M;Mather KA;Mattheisen M;Mazoyer B;McKay DR;McWhirter R;Milaneschi Y;Mirza-Schreiber N;Muetzel RL;Maniega SM;Nho K;Nugent AC;Loohuis LM;Oosterlaan J;Papmeyer M;Pappa I;Pirpamer L;Pudas S;Pütz B;Rajan KB;Ramasamy A;Richards JS;Risacher SL;Roiz-Santiañez R;Rommelse N;Rose EJ;Royle NA;Rundek T;Sämann PG;Satizabal CL;Schmaal L;Schork AJ;Shen L;Shin J;Shumskaya E;Smith AV;Sprooten E;Strike LT;Teumer A;Thomson R;Tordesillas-Gutierrez D;Toro R;Trabzuni D;Vaidya D;Van der Grond J;Van der Meer D;Van Donkelaar MM;Van Eijk KR;Van Erp TG;Van Rooij D;Walton E;Westlye LT;Whelan CD;Windham BG;Winkler AM;Woldehawariat G;Wolf C;Wolfers T;Xu B;Yanek LR;Yang J;Zijdenbos A;Zwiers MP;Agartz I;Aggarwal NT;Almasy L;Ames D;Amouyel P;Andreassen OA;Arepalli S;Assareh AA;Barral S;Bastin ME;Becker DM;Becker JT;Bennett DA;Blangero J;van Bokhoven H;Boomsma DI;Brodaty H;Brouwer RM;Brunner HG;Buckner RL;Buitelaar JK;Bulayeva KB;Cahn W;Calhoun VD;Cannon DM;Cavalleri GL;Chen C;Cheng CY;Cichon S;Cookson MR;Corvin A;Crespo-Facorro B;Curran JE;Czisch M;Dale AM;Davies GE;De Geus EJ;De Jager PL;de Zubicaray GI;Delanty N;Depondt C;DeStefano AL;Dillman A;Djurovic S;Donohoe G;Drevets WC;Duggirala R;Dyer TD;Erk S;Espeseth T;Evans DA;Fedko IO;Fernández G;Ferrucci L;Fisher SE;Fleischman DA;Ford I;Foroud TM;Fox PT;Francks C;Fukunaga M;Gibbs JR;Glahn DC;Gollub RL;Göring HH;Grabe HJ;Green RC;Gruber O;Gudnason V;Guelfi S;Hansell NK;Hardy J;Hartman CA;Hashimoto R;Hegenscheid K;Heinz A;Le Hellard S;Hernandez DG;Heslenfeld DJ;Ho BC;Hoekstra PJ;Hoffmann W;Hofman A;Holsboer F;Homuth G;Hosten N;Hottenga JJ;Hulshoff Pol HE;Ikeda M;Ikram MK;Jack CR Jr;Jenkinson M;Johnson R;Jönsson EG;Jukema JW;Kahn RS;Kanai R;Kloszewska I;Knopman DS;Kochunov P;Kwok JB;Lawrie SM;Lemaître H;Liu X;Longo DL;Longstreth WT Jr;Lopez OL;Lovestone S;Martinez O;Martinot JL;Mattay VS;McDonald C;McIntosh AM;McMahon KL;McMahon FJ;Mecocci P;Melle I;Meyer-Lindenberg A;Mohnke S;Montgomery GW;Morris DW;Mosley TH;Mühleisen TW;Müller-Myhsok B;Nalls MA;Nauck M;Nichols TE;Niessen WJ;Nöthen MM;Nyberg L;Ohi K;Olvera RL;Ophoff RA;Pandolfo M;Paus T;Pausova Z;Penninx BW;Pike GB;Potkin SG;Psaty BM;Reppermund S;Rietschel M;Roffman JL;Romanczuk-Seiferth N;Rotter JI;Ryten M;Sacco RL;Sachdev PS;Saykin AJ;Schmidt R;Schofield PR;Sigurdsson S;Simmons A;Singleton A;Sisodiya SM;Smith C;Smoller JW;Soininen H;Srikanth V;Steen VM;Stott DJ;Sussmann JE;Thalamuthu A;Tiemeier H;Toga AW;Traynor BJ;Troncoso J;Turner JA;Tzourio C;Uitterlinden AG;Hernández MC;Van der Brug M;Van der Lugt A;Van der Wee NJ;Van Duijn CM;Van Haren NE;Van T Ent D;Van Tol MJ;Vardarajan BN;Veltman DJ;Vernooij MW;Völzke H;Walter H;Wardlaw JM;Wassink TH;Weale ME;Weinberger DR;Weiner MW;Wen W;Westman E;White T;Wong TY;Wright CB;Zielke HR;Zonderman AB;Deary IJ;DeCarli C;Schmidt H;Martin NG;De Craen AJ;Wright MJ;Launer LJ;Schumann G;Fornage M;Franke B;Debette S;Medland SE;Ikram MA;Thompson PM
• 通讯作者: Thompson PM

Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study.

• DOI: 10.1007/s00401-020-02255-2
• 发表时间: 2021-03
• 期刊: Acta neuropathologica
• 影响因子: 12.7
• 作者: Attems J;Toledo JB;Walker L;Gelpi E;Gentleman S;Halliday G;Hortobagyi T;Jellinger K;Kovacs GG;Lee EB;Love S;McAleese KE;Nelson PT;Neumann M;Parkkinen L;Polvikoski T;Sikorska B;Smith C;Grinberg LT;Thal DR;Trojanowski JQ;McKeith IG
• 通讯作者: McKeith IG

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke.

• DOI: 10.1111/nan.12116
• 发表时间: 2014-12
• 期刊: Neuropathology and applied neurobiology
• 影响因子: 5
• 作者: Bailey EL;McBride MW;Beattie W;McClure JD;Graham D;Dominiczak AF;Sudlow CL;Smith C;Wardlaw JM
• 通讯作者: Wardlaw JM