Characterize the extent, distribution and range of pathologies contributing to TReND in cTBI patients and CTE-NC in participating brain banks

描述参与脑库的 cTBI 患者和 CTE-NC 中导致 TReND 的病理的程度、分布和范围

• 批准号: 10483205
• 负责人: Douglas Hamilton Smith
• 金额: $ 16.29万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10483205
• 关键词: Age; Aging; Alzheimer' s disease pathology; Amyloid beta-Protein; Attention; Autopsy; Brain; Characteristics; Chronic; Clinical; Common Data Element; Communities; Complex; Consensus; Data; Diagnosis; Diagnostic; Elements; Evaluation; Exposure to; Individual; Injury; International; Lewy Bodies; Microscopy; Nerve Degeneration; Neurodegenerative Disorders; Output; Pathology; Patients; Pattern; Phase; Population; Prevalence; Protocols documentation; Reporting; Research Design; Research Project Grants; Risk; Sampling; Series; Severities; Stains; Standardization; Survivors; TBI Patients; Traumatic Brain Injury; aged; axonal degeneration; chronic traumatic encephalopathy; comparative; cost; digital; mild traumatic brain injury; neuroinflammation; neuron loss; neuropathology; protein TDP-43; tau Proteins; tau-1; tissue resource; validation studies; white matter

Research Project 1 SUMMARY There is growing concern over the association between traumatic brain injury (TBI) and progressive neurodegenerative changes, in particular those that are characterized as chronic traumatic encephalopathy (CTE). First recognized in boxers, it was not until descriptions of CTE pathology in non-boxer athletes attracted widespread attention. However, reflecting the paucity of cases described, current consensus criteria for the neuropathological assessment of CTE remain preliminary, with the associated clinical consequences of this pathology unclear. Furthermore, the narrow focus on CTE and its characteristic tau pathologies has come at the cost of characterizing many other neuropathologies that have also been observed in CTE cases and in all forms of TBI. Current reporting in CTE largely focuses on p-tau pathologies, which are thought to define its pathognomonic neuropathology. However, rather than a single proteinopathy, wider, unbiased autopsy reporting of TBI related neurodegeneration (TReND) in chronic TBI (cTBI) survivors across a full spectrum of injury severities documents far more varied complex neuropathologies. Furthermore, the pathologies encountered in cTBI patients often are mixed, with multiple proteinopathies, particularly in aged patients. As such, there is growing recognition that TReND in TBI survivors is a complex polypathology, just one element of which might be described by current definitions of CTE. We propose to characterize the extent, distribution and range of pathologies contributing to TReND in cTBI patients across a spectrum TBI types and severities. In addition, we will develop and validate operational criteria for the neuropathological diagnosis of TReND pathologies using established protocols that have proven successful for wider neurodegenerative disease.

研究项目1