Discovering novel regulators of stem cell behaviour in a highly regenerative context
在高度再生的环境中发现干细胞行为的新型调节因子
基本信息
- 批准号:MR/M000133/1
- 负责人:
- 金额:$ 55.16万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2014
- 资助国家:英国
- 起止时间:2014 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The whole of biomedical research is underpinned by key detailed experiments performed in simple model organisms. These animals provide relatively cheap and rapid systems in which to make novel discoveries, with nearly all fundamental cell and molecular biomedical processes having their first genetic description in either the fruit fly Drosophila melanogaster or the nematode Caenorhabditis elegans. This is because all metazoan animals share conserved evolutionary features that were present in their last common ancestor. The reason that these two model organisms have been so extensively used is that historically they were amenable to genetic analysis. In the last twenty years a plethora of new ways of studying how genes work have been invented such that it is possible to study many other animals in great detail. As these animals have all evolved independently it is possible for them to have features in common with our own biology that the established models do not. For example, neither the fruit fly nor the nematode make extensive use of adult stem cells during their life history in contrast to mammals. Here we propose to use planarians, another simple animal that does use adult stem cells as part of its life history. These animals can use their stem cells to regenerate their whole body, including the brain. This is because their adult stem cells are able to divide and make new tissues almost indefinitely and we have already shown that some of the genes controlling planarian stem cells are likely to have conserved functions in humans. Many of these genes may have roles in human diseases when they are mutated to become over or under active We would like to find these genes and describe their functions in controlling stem cell biology as this is likely to be very informative about what they might do in humans and how they might be involved in disease proceeses, particularly those cancers that originate from from rogue adult stem cells in mammals form tumors.In order to achieve this we have designed a sensitive and rapid method forstudying the function of novel genes both in adult stem cells and in their environment, as both are likely to be important for understanding how stem cells behave and mistakes this behaviour can lead to human diseases, particularly cancer.
整个生物医学研究都是由在简单的模式生物中进行的关键详细实验支撑的。这些动物提供了相对便宜和快速的系统,使新的发现,几乎所有的基本细胞和分子生物医学过程的第一个遗传描述在果蝇黑腹果蝇或线虫秀丽隐杆线虫。这是因为所有的后生动物都具有它们最后一个共同祖先所具有的保守的进化特征。这两种模式生物之所以被广泛使用,是因为它们在历史上易于进行遗传分析。在过去的20年里,研究基因如何工作的新方法层出不穷,因此有可能详细研究许多其他动物。由于这些动物都是独立进化的,因此它们可能具有与我们自己的生物学相同的特征,而这些特征是现有模型所没有的。例如,与哺乳动物相比,果蝇和线虫在其生活史中都没有广泛使用成体干细胞。在这里,我们建议使用真涡虫,另一种简单的动物,使用成体干细胞作为其生活史的一部分。这些动物可以使用它们的干细胞来再生它们的整个身体,包括大脑。这是因为它们的成体干细胞能够几乎无限期地分裂和制造新的组织,我们已经表明,控制涡虫干细胞的一些基因可能在人类中具有保守的功能。许多这些基因可能在人类疾病中发挥作用,当它们突变为过度或不活跃时,我们希望找到这些基因并描述它们在控制干细胞生物学中的功能,因为这可能是关于它们在人类中可能做什么以及它们如何参与疾病过程的信息。特别是那些起源于哺乳动物中的流氓成体干细胞的癌症形成肿瘤。为了实现这一目标,我们设计了一种灵敏而快速的方法来研究成体干细胞中新基因的功能,干细胞及其环境的研究,因为这两者对于理解干细胞的行为和错误的行为可能导致人类疾病,特别是癌症都很重要。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
ACME dissociation: a versatile cell fixation-dissociation method for single-cell transcriptomics.
- DOI:10.1186/s13059-021-02302-5
- 发表时间:2021-04-08
- 期刊:
- 影响因子:12.3
- 作者:García-Castro H;Kenny NJ;Iglesias M;Álvarez-Campos P;Mason V;Elek A;Schönauer A;Sleight VA;Neiro J;Aboobaker A;Permanyer J;Irimia M;Sebé-Pedrós A;Solana J
- 通讯作者:Solana J
The abrogation of condensin function provides independent evidence for defining the self-renewing population of pluripotent stem cells
凝缩蛋白功能的废除为定义多能干细胞的自我更新群体提供了独立的证据
- DOI:10.1101/143339
- 发表时间:2017
- 期刊:
- 影响因子:0
- 作者:Lai A
- 通讯作者:Lai A
The abrogation of condensin function provides independent evidence for defining the self-renewing population of pluripotent stem cells.
凝缩蛋白功能的废除为定义多能干细胞的自我更新群体提供了独立的证据。
- DOI:10.1016/j.ydbio.2017.07.023
- 发表时间:2018-01-15
- 期刊:
- 影响因子:2.7
- 作者:Lai AG;Kosaka N;Abnave P;Sahu S;Aboobaker AA
- 通讯作者:Aboobaker AA
The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion.
- DOI:10.7554/elife.20062
- 发表时间:2016-11-16
- 期刊:
- 影响因子:7.7
- 作者:Kao D;Lai AG;Stamataki E;Rosic S;Konstantinides N;Jarvis E;Di Donfrancesco A;Pouchkina-Stancheva N;Sémon M;Grillo M;Bruce H;Kumar S;Siwanowicz I;Le A;Lemire A;Eisen MB;Extavour C;Browne WE;Wolff C;Averof M;Patel NH;Sarkies P;Pavlopoulos A;Aboobaker A
- 通讯作者:Aboobaker A
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Aziz Aboobaker其他文献
17-P036 How are the chromosome ends of immortal worms maintained?
- DOI:
10.1016/j.mod.2009.06.757 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Thomas Tan;Edward Louis;Aziz Aboobaker - 通讯作者:
Aziz Aboobaker
05-P016 DNA methylation in the freshwater planarian <em>Schmidtea mediterranea</em>
- DOI:
10.1016/j.mod.2009.06.221 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Priscilla Lo;Farah Jaber;Aziz Aboobaker - 通讯作者:
Aziz Aboobaker
19-P020 <em>Schmidtea mediterranea</em>’s matrix metalloproteases and their importance for regeneration and survival
- DOI:
10.1016/j.mod.2009.06.808 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Mohammed Bakkali;Aziz Aboobaker - 通讯作者:
Aziz Aboobaker
19-P022 The roles of <em>Drosophila melanogaster</em> developmental gene orthologues in <em>Schmidtea mediterranea</em> regeneration
- DOI:
10.1016/j.mod.2009.06.810 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Suthira Owlarn;Aziz Aboobaker - 通讯作者:
Aziz Aboobaker
19-P023 Anterior regeneration in the planarian <em>Schmidtea mediterranea</em>: Revisiting the works of T.H. Morgan and C.M. Child
- DOI:
10.1016/j.mod.2009.06.811 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Deborah Evans;Aziz Aboobaker - 通讯作者:
Aziz Aboobaker
Aziz Aboobaker的其他文献
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{{ truncateString('Aziz Aboobaker', 18)}}的其他基金
Understanding the regulation of adult stem cell migration during regeneration.
了解再生过程中成体干细胞迁移的调节。
- 批准号:
MR/T028165/1 - 财政年份:2021
- 资助金额:
$ 55.16万 - 项目类别:
Research Grant
Post-transcriptional control of adult stem cell pluripotency.
成体干细胞多能性的转录后控制。
- 批准号:
BB/L026627/1 - 财政年份:2014
- 资助金额:
$ 55.16万 - 项目类别:
Research Grant
The evolution and molecular basis of adaptations to Telomere Biology in immortal worms.
永生蠕虫端粒生物学适应的进化和分子基础。
- 批准号:
BB/K007564/1 - 财政年份:2013
- 资助金额:
$ 55.16万 - 项目类别:
Research Grant
What are the signals that allow the correct differentiation of neoblast stem cells during planarian regeneration?
在真涡虫再生过程中,哪些信号可以使新生细胞干细胞正确分化?
- 批准号:
BB/E01030X/1 - 财政年份:2007
- 资助金额:
$ 55.16万 - 项目类别:
Research Grant
Immortal worms and stem cells: how do planarians replace and rescale during regeneration?
不朽的蠕虫和干细胞:涡虫在再生过程中如何替换和重新缩放?
- 批准号:
G0601133/1 - 财政年份:2007
- 资助金额:
$ 55.16万 - 项目类别:
Research Grant
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