ACTG 807

ACTG 807

• 批准号: 2353467
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2353467
• 关键词: blood chemistry; clinical research; clinical trials; cytomegalovirus; drug resistance; human subject; retinitis; urinalysis

Depression is common, particularly among the elderly. It sometimes heralds, and frequently accompanies, other diseases such as Alzheimer's or Parkinson's disease which are more prevalent in old age. Depression leads to significant morbidity and mortality, especially among the elderly, through difficulties with activities of daily living, worsening of medical problems, and an increased rate of suicide. However, study of the functional brain imaging correlates of idiopathic (or endogenous) depression is difficult, perhaps because of clinical and biological heterogeneity. Depression in neuropsychiatric disorders, because the neuropathology is well characterized, can serve as a model for idiopathic depression. We propose to study the phenomenology and functional brain imaging correlates of depression in two neuropsychiatric diseases with well-characterized clinical syndromes and neuropathology (Alzheimer's and Huntington's disease) using single photon emission tomography (SPECT). Such comparative studies will address the potential existence of diseasespecific neurophysiologic and symptom profiles in depression. Depression in Alzheimer's and Huntington's disease is associated with specific disturbances in cerebral blood flow as measured by single photon emission tomography. Specifically, depressed patients with AD and HD will have in common inferior frontal hypoperfusion compared to non-depressed patients with these diseases. We predict blood flow abnormalities will be characteristic of the symptomatic state. To determine the functional brain imaging (AD) and Huntington's (HD). We will compare depressed and non-depressed subjects with these diseases by measuring cerebral blood flow by single-photon emission tomography (SPECT), and evaluate patients on scales of depression, dementia, and functional disability.

抑郁症很常见，尤其是在老年人中。 它有时 预示着，并经常伴随着其他疾病，如阿尔茨海默氏症 或帕金森氏症，这些疾病在老年人中更为普遍。 抑郁 导致严重的发病率和死亡率，特别是在 老年人，由于日常生活活动困难， 医疗问题和自杀率的上升。 然而，研究 脑功能成像与特发性（或内源性） 抑郁症是困难的，也许是因为临床和生物学上的原因。 异质性 神经精神疾病中的抑郁症，因为 神经病理学特征很好，可以作为模型， 特发性抑郁症 我们建议研究现象学， 脑功能成像与抑郁症的相关性 具有明确特征的临床综合征的神经精神疾病， 使用单一神经病理学（阿尔茨海默病和亨廷顿病） 光子发射断层扫描（SPECT）。 这种比较研究将 解决疾病特异性神经生理学和 抑郁症的症状特征 阿尔茨海默病和亨廷顿病的抑郁症与 通过单次测量脑血流的特定紊乱 光子发射断层扫描 具体来说，患有AD的抑郁症患者 与HD相比，HD常见的是下额叶灌注不足 患有这些疾病的非抑郁症患者。 我们预测血流 异常将是症状状态的特征。 测定脑功能成像（AD）和亨廷顿病（HD）。 我们将比较抑郁症和非抑郁症受试者与这些疾病 通过单光子发射断层扫描测量脑血流量 （SPECT），并评估患者的抑郁症，痴呆症， 功能性残疾