Obstetric, lifestyle and genetic determinants of vascular and metabolic traits in women in early middle-age

中年早期女性血管和代谢特征的产科、生活方式和遗传决定因素

• 批准号: G0701594/1
• 负责人: Abigail Fraser
• 金额: $ 58.54万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701594%2F1
• 关键词: Obstetric; lifestyle; genetic; determinants; vascular

The aim of this study is to identify the risk factors, including changes during pregnancy (such as changes in weight and blood pressure), different patterns of change in lifestyle factors such as smoking habits and physical activity, and genetic factors, that determine the variations in atherosclerosis and other vascular and metabolic traits in women in their mid-40s. Cardiovascular disease (CVD) is the commonest cause of death among women in the UK, with 113,140 women (37% of the total number of deaths in all women in the UK) dying of CVD and 11% living with either coronary heart disease or stroke in 2004. Study participants will be mothers from the Avon Longitudinal Study of Parents and Children. For these women we already have over 15 years of prospectively collected genetic, lifestyle and obstetric data collected repeatedly since their index pregnancy in the early 1990s. 7,000 women (average age 44) will be recruited to participate in a clinical examination. This will include fasting blood samples for insulin, glucose and lipid measurements, DXA determined fat mass and carotid intima media thickness (a measure of atherosclerosis). This work will provide the necessary evidence base for developing effective interventions aimed at preventing CVD in women.

这项研究的目的是确定风险因素，包括怀孕期间的变化（如体重和血压的变化），生活方式因素的不同变化模式，如吸烟习惯和体育活动，以及遗传因素，这些因素决定了40多岁女性动脉粥样硬化和其他血管和代谢特征的变化。心血管疾病（CVD）是英国妇女最常见的死亡原因，2004年有113，140名妇女（占英国所有妇女死亡总数的37%）死于CVD，11%患有冠心病或中风。研究参与者将是来自雅芳父母和孩子纵向研究的母亲。对于这些妇女，我们已经有超过15年的前瞻性收集的遗传，生活方式和产科数据，自20世纪90年代初他们的指数怀孕以来反复收集。将招募7 000名妇女（平均年龄44岁）参加临床检查。这将包括用于胰岛素、葡萄糖和脂质测量的空腹血液样本，DXA确定的脂肪质量和颈动脉内膜中层厚度（动脉粥样硬化的测量）。这项工作将提供必要的证据基础，制定有效的干预措施，旨在预防心血管疾病的妇女。