UKDP: Integrated DEmentiA research environment (IDEA)
UKDP:综合痴呆症研究环境 (IDEA)
基本信息
- 批准号:MR/M02492X/1
- 负责人:
- 金额:$ 241.97万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2015
- 资助国家:英国
- 起止时间:2015 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The UK Dementias Platform (UKDP) is a radically new approach to dementias research. It brings together data fromaround 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways ofslowing it down. The platform has been funded to the level of £12M.In this proposal we want to improve UK infrastructure for dementia research so that the most can be made of theopportunity provided by UKDP. We wan to improve the infrastructure by buying important pieces of equipment that will putthe UK at the forefront of dementia research worldwide and by establishing networks of scientists who will work together tomake best use of the equipment.The three themes of the proposal are imaging, informatics and stem cells.For imaging we want to establish a network of PET/MR scanning facilities across the UK so that the molecular processesgoing on inside the brain that cause dementia can be studied.For informatics we want to be bring together bas many different types of data as possible and make it easy as possible forscientists to use themFor stem cells we want to take cells form adults with and without dementia to find out how cells change as the dementiasprocess begins and progresses.We believe these proposals will raise standards, reduce costs, and deliver innovative and coordinated research, makingthe UK an internationally unique place to study dementia.
英国痴呆症平台(UKDP)是一种全新的痴呆症研究方法。它汇集了来自22个队列的约200万研究参与者的数据,试图发现痴呆症的原因,并找到减缓痴呆症的方法。该平台已获得1200万英镑的融资。在这项提案中,我们希望改善英国痴呆症研究的基础设施,以便最大限度地利用UKDP提供的机会。我们希望通过购买重要的设备来改善基础设施,这些设备将使英国处于全球痴呆症研究的前沿,并通过建立科学家网络来共同努力,充分利用这些设备。提案的三个主题是成像、信息学和干细胞。在成像方面,我们希望在英国建立一个PET/MR扫描设备网络,这样就可以研究大脑内部导致痴呆的分子过程。在信息学方面,我们希望汇集尽可能多的不同类型的数据,并使科学家尽可能容易地使用它们。在干细胞方面,我们希望从患有和不患有痴呆症的成年人身上提取细胞,以发现随着痴呆症过程的开始和发展,细胞是如何变化的。我们相信这些提案将提高标准,降低成本,并提供创新和协调的研究,使英国成为研究痴呆症的国际独特之地。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: A preliminary study in a Croatian cohort.
- DOI:10.1002/brb3.1128
- 发表时间:2018-11
- 期刊:
- 影响因子:3.1
- 作者:Babić Leko M;Willumsen N;Nikolac Perković M;Klepac N;Borovečki F;Hof PR;Sonicki Z;Pivac N;de Silva R;Šimić G
- 通讯作者:Šimić G
Autophagy in healthy aging and disease.
健康衰老和疾病中的自噬。
- DOI:10.1038/s43587-021-00098-4
- 发表时间:2021-08
- 期刊:
- 影响因子:0
- 作者:Aman Y;Schmauck-Medina T;Hansen M;Morimoto RI;Simon AK;Bjedov I;Palikaras K;Simonsen A;Johansen T;Tavernarakis N;Rubinsztein DC;Partridge L;Kroemer G;Labbadia J;Fang EF
- 通讯作者:Fang EF
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.
- DOI:10.1371/journal.pone.0184104
- 发表时间:2017
- 期刊:
- 影响因子:3.7
- 作者:Arber C;Angelova PR;Wiethoff S;Tsuchiya Y;Mazzacuva F;Preza E;Bhatia KP;Mills K;Gout I;Abramov AY;Hardy J;Duce JA;Houlden H;Wray S
- 通讯作者:Wray S
Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout
- DOI:10.1093/braincomms/fcz024
- 发表时间:2019-01-01
- 期刊:
- 影响因子:4.8
- 作者:Arber, Charles;Villegas-Llerena, Claudio;Wray, Selina
- 通讯作者:Wray, Selina
Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro.
- DOI:10.1016/j.matbio.2019.06.009
- 发表时间:2020-01
- 期刊:
- 影响因子:0
- 作者:Ashworth JC;Thompson JL;James JR;Slater CE;Pijuan-Galitó S;Lis-Slimak K;Holley RJ;Meade KA;Thompson A;Arkill KP;Tassieri M;Wright AJ;Farnie G;Merry CLR
- 通讯作者:Merry CLR
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Thomas Warner其他文献
Probiotic Effects of Feeding Heat-Killed <em>Lactobacillus acidophilus</em> and <em>Lactobacillus casei</em> to <em>Candida albicans</em>-Colonized Immunodeficient Mice
- DOI:
10.4315/0362-028x-63.5.638 - 发表时间:
2000-05-01 - 期刊:
- 影响因子:
- 作者:
R.Doug Wagner;Carey Pierson;Thomas Warner;Margaret Dohnalek;Milo Hilty;Edward Balish - 通讯作者:
Edward Balish
The cardio-oncology multidisciplinary team: beyond the basics
- DOI:
10.1186/s40959-025-00369-8 - 发表时间:
2025-07-26 - 期刊:
- 影响因子:3.200
- 作者:
Joshua D. Bennetts;Trent D. Williams;Craig J. Beavers;Heather N. Moore;Cameron Robson;Thomas Warner;Susan Dent;Aaron L. Sverdlov;Doan T.M. Ngo - 通讯作者:
Doan T.M. Ngo
Testing a device to replace the leech for treating venous congestion.
测试一种替代水蛭治疗静脉充血的装置。
- DOI:
10.1001/archfaci.5.1.70 - 发表时间:
2003 - 期刊:
- 影响因子:0
- 作者:
G. Hartig;N. Connor;Thomas Warner;D. Heisey;M. Sarmadi;Michael L Conforti - 通讯作者:
Michael L Conforti
Formation of Enol Ethers by Radical Decarboxylation of α-Alkoxy β-Phenylthio Acids.
通过 α-烷氧基 β-苯硫酸的自由基脱羧形成烯醇醚。
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:3.6
- 作者:
A. Palanivel;S. Mubeen;Thomas Warner;N. Ahmed;D. Clive - 通讯作者:
D. Clive
Thomas Warner的其他文献
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{{ truncateString('Thomas Warner', 18)}}的其他基金
UCL Neurodegenerative Disease Human Tissue Resource
伦敦大学学院神经退行性疾病人体组织资源
- 批准号:
MR/Y00440X/1 - 财政年份:2024
- 资助金额:
$ 241.97万 - 项目类别:
Research Grant
Incorporating the Uncertainty of Atmosphere-Land Surface Interactions into Ensemble Forecasts
将大气-地表相互作用的不确定性纳入集合预报
- 批准号:
0130154 - 财政年份:2002
- 资助金额:
$ 241.97万 - 项目类别:
Continuing Grant
Ensemble Forecasting of Convective Weather Events Using a Mesoscale Model
使用中尺度模型对对流天气事件进行集合预报
- 批准号:
9501532 - 财政年份:1995
- 资助金额:
$ 241.97万 - 项目类别:
Continuing Grant
The Assimilation of Data from Satellite Data Sources for Mesoscale Analyses in Support of SHEBA
卫星数据源数据同化用于支持 SHEBA 的中尺度分析
- 批准号:
9504300 - 财政年份:1995
- 资助金额:
$ 241.97万 - 项目类别:
Standard Grant
Numerical Studies of the Interaction of Mesoscale Convective Systems With the Tropical Ocean-Atmosphere Environment
中尺度对流系统与热带海洋-大气环境相互作用的数值研究
- 批准号:
9024434 - 财政年份:1991
- 资助金额:
$ 241.97万 - 项目类别:
Continuing Grant
A Study of the Effect of a Time-Varying Moist Potential Vorticity on the Evolution of Conditional Symmetric Instability
时变湿位涡对条件对称不稳定性演化的影响研究
- 批准号:
9019010 - 财政年份:1991
- 资助金额:
$ 241.97万 - 项目类别:
Continuing Grant
Dynamic and Thermodynamic Effects of the Tibetan Plateau on Mesoscale Vortex Development
青藏高原对中尺度涡发展的动力和热力学效应
- 批准号:
8911626 - 财政年份:1989
- 资助金额:
$ 241.97万 - 项目类别:
Continuing Grant
Studies of the Requirements for the Numerical Simulations ofMesoscale Rainbands Forced by Conditional Symmetric Instability
条件对称不稳定性驱动的中尺度雨带数值模拟要求研究
- 批准号:
8716204 - 财政年份:1987
- 资助金额:
$ 241.97万 - 项目类别:
Continuing Grant
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