UKDP: Integrated DEmentiA research environment (IDEA)

UKDP：综合痴呆症研究环境 (IDEA)

• 批准号: MR/M02492X/1
• 负责人: Thomas Warner
• 金额: $ 241.97万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM02492X%2F1
• 关键词: UKDP; Integrated; DEmentiA; research; environment

The UK Dementias Platform (UKDP) is a radically new approach to dementias research. It brings together data fromaround 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways ofslowing it down. The platform has been funded to the level of £12M.In this proposal we want to improve UK infrastructure for dementia research so that the most can be made of theopportunity provided by UKDP. We wan to improve the infrastructure by buying important pieces of equipment that will putthe UK at the forefront of dementia research worldwide and by establishing networks of scientists who will work together tomake best use of the equipment.The three themes of the proposal are imaging, informatics and stem cells.For imaging we want to establish a network of PET/MR scanning facilities across the UK so that the molecular processesgoing on inside the brain that cause dementia can be studied.For informatics we want to be bring together bas many different types of data as possible and make it easy as possible forscientists to use themFor stem cells we want to take cells form adults with and without dementia to find out how cells change as the dementiasprocess begins and progresses.We believe these proposals will raise standards, reduce costs, and deliver innovative and coordinated research, makingthe UK an internationally unique place to study dementia.

英国痴呆症平台（UKDP）是一种全新的痴呆症研究方法。它汇集了来自 22 个队列的约 2,000,000 名研究参与者的数据，试图发现痴呆症的原因并找出减缓痴呆症发展的方法。该平台已获得 1200 万英镑的资助。在这项提案中，我们希望改善英国痴呆症研究的基础设施，以便最大限度地利用 UKDP 提供的机会。我们希望通过购买重要设备来改善基础设施，使英国处于全球痴呆症研究的前沿，并建立科学家网络，共同努力充分利用这些设备。该提案的三个主题是成像、信息学和干细胞。对于成像，我们希望在英国各地建立一个 PET/MR 扫描设施网络，以便能够了解大脑内部发生的导致痴呆症的分子过程。 对于信息学，我们希望将尽可能多的不同类型的数据汇集在一起，并让科学家尽可能轻松地使用它们。对于干细胞，我们希望从患有或未患有痴呆症的成年人身上获取细胞，以了解随着痴呆症过程的开始和进展，细胞如何变化。我们相信这些建议将提高标准，降低成本，并提供创新和协调的研究，使英国成为研究痴呆症的国际独特场所。

项目成果

Association of MAPT haplotype-tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: A preliminary study in a Croatian cohort.

• DOI: 10.1002/brb3.1128
• 发表时间: 2018-11
• 期刊: Brain and behavior
• 影响因子: 3.1
• 作者: Babić Leko M;Willumsen N;Nikolac Perković M;Klepac N;Borovečki F;Hof PR;Sonicki Z;Pivac N;de Silva R;Šimić G
• 通讯作者: Šimić G

Autophagy in healthy aging and disease.

健康衰老和疾病中的自噬。

• DOI: 10.1038/s43587-021-00098-4
• 发表时间: 2021-08
• 期刊: Nature aging
• 作者: Aman Y;Schmauck-Medina T;Hansen M;Morimoto RI;Simon AK;Bjedov I;Palikaras K;Simonsen A;Johansen T;Tavernarakis N;Rubinsztein DC;Partridge L;Kroemer G;Labbadia J;Fang EF
• 通讯作者: Fang EF

iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.

• DOI: 10.1371/journal.pone.0184104
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Arber C;Angelova PR;Wiethoff S;Tsuchiya Y;Mazzacuva F;Preza E;Bhatia KP;Mills K;Gout I;Abramov AY;Hardy J;Duce JA;Houlden H;Wray S
• 通讯作者: Wray S

Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout

• DOI: 10.1093/braincomms/fcz024
• 发表时间: 2019-01-01
• 期刊: BRAIN COMMUNICATIONS
• 影响因子: 4.8
• 作者: Arber, Charles;Villegas-Llerena, Claudio;Wray, Selina
• 通讯作者: Wray, Selina

Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro.

• DOI: 10.1016/j.matbio.2019.06.009
• 发表时间: 2020-01
• 期刊: Matrix biology : journal of the International Society for Matrix Biology
• 作者: Ashworth JC;Thompson JL;James JR;Slater CE;Pijuan-Galitó S;Lis-Slimak K;Holley RJ;Meade KA;Thompson A;Arkill KP;Tassieri M;Wright AJ;Farnie G;Merry CLR
• 通讯作者: Merry CLR