Newton001: Salivary gland development and regeneration

Newton001：唾液腺发育和再生

• 批准号: MR/M026426/1
• 负责人: Abigail Tucker
• 金额: $ 5.31万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM026426%2F1
• 关键词: Newton001; Salivary; gland; development; regeneration

One of the factors that significantly impinges on the quality of life among elderly people is a decrease in salivary flow (hyposalivation) and a dry mouth (xerostomia). The prevalence of xerostomia increases with age and affects approximately 30% of people aged 65 or older. Xerostomia leads to problems with speech, taste digestion, mastication and swallowing, and a high incidence of dental caries and candida. There is no cure but chewing gum and artificial saliva are used to relieve the symptoms in many cases. Given the large numbers of sufferers, and the potential increase in incidence given our aging population, it is important to understand the mechanisms that drive xerostomia so that new therapies can be found. Xerostomia can be caused by a number of different factors. Certain medicines cause xerostomia as a side effect, while xerostomia is also a central feature of the auto-immune disease Sjögren Syndrome, which affects up to 3-4% of older adults. Xerostomia is also a feature of some genetic disorders that affect the salivary glands, such as LADD syndrome and ALSG, and is frequently a side effect of head and neck radiotherapy. We aim to study xerostomia using various mouse models of gland dysfunction and regeneration.This application aims to combine knowledge of salivary gland development with knowledge of salivary gland stem cells from mouse and translate these findings into humans. This is possible through combining research from basic scientists in the UK and clinical researchers in Brazil, with the ultimate goal of creating innovative methods to treat xerostomia.

影响老年人生活质量的因素之一是唾液流量减少（唾液分泌不足）和口干（口干）。口干症的患病率随着年龄的增长而增加，大约30%的65岁或以上的人受到影响。口腔干燥症导致言语、味觉消化、咀嚼和吞咽问题，以及龋齿和念珠菌的高发病率。没有治愈方法，但在许多情况下，咀嚼口香糖和人工唾液可以缓解症状。由于患者数量众多，并且由于人口老龄化，发病率可能会增加，因此了解导致口干症的机制非常重要，以便找到新的治疗方法。口干症可以由许多不同的因素引起。某些药物会导致口干症作为副作用，而口干症也是自身免疫性疾病舍格伦综合征的中心特征，影响高达3-4%的老年人。口干症也是一些影响唾液腺的遗传性疾病的特征，如拉德综合征和ALSG，并且经常是头颈部放疗的副作用。我们的目的是研究口干症使用各种小鼠模型的腺体功能障碍和regeneration.This应用程序的目的是联合收割机知识的唾液腺发育与知识的唾液腺干细胞从小鼠和翻译这些发现到人类。通过结合英国基础科学家和巴西临床研究人员的研究，最终目标是创造治疗口干症的创新方法。

项目成果

Apoptosis-associated protein expression in human salivary gland morphogenesis.

• DOI: 10.1016/j.archoralbio.2016.05.013
• 发表时间: 2016-09
• 期刊: Archives of oral biology
• 影响因子: 3
• 作者: T. Teshima;R. F. Ianez;C. Coutinho-Camillo;A. Tucker;S. Lourenço

Salivary Gland Development in Culture.

• DOI: 10.1007/978-1-0716-1847-9_19
• 发表时间: 2022-01-01
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Gaete, Marcia;Teshima, Tathyane H N;Tucker, Abigail S
• 通讯作者: Tucker, Abigail S