Middle ear cavitation and mesenchymal clearance: links with deafness and otitis media

中耳空化和间充质清除:与耳聋和中耳炎的联系

基本信息

  • 批准号:
    G1001232/1
  • 负责人:
  • 金额:
    $ 52.74万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2011
  • 资助国家:
    英国
  • 起止时间:
    2011 至 无数据
  • 项目状态:
    已结题

项目摘要

As one of the five human senses, hearing not only has critical biological function, but is also crucially important for our integration within society. Worldwide the main cause of mild to moderate hearing impairment in children is chronic middle ear inflammation (otitis media). In the UK around 200,000 children suffer from repeated middle ear infections each year. In the developed world, implantation of ventilation tubes to combat otitis media is the most common reason for surgery in children and is a substantial burden on the healthcare services. Given the number of individuals affected, and the debilitating nature of chronic OM, it is vital that a better understanding of the factors that can influence the onset of OM are addressed. The abnormal presence of mesenchyme in the middle ear has been shown to be closely linked with chronic cases of otitis media. During normal ear development mesenchymal tissue is lost from the middle ear to create an air-filled cavity. In this grant we wish to study why mesenchyme remains in the ears of some children, using the mouse as a model. We will investigate how the middle ear cavity normally forms, what goes wrong in cases where the mesenchyme is not removed, and will then try and correct this defect. This work will help our understanding of middle ear disease, and aims to initiate new methods to treat problems.
作为人类五种感官之一,听觉不仅具有重要的生物学功能,而且对我们融入社会也至关重要。在世界范围内,造成儿童轻中度听力障碍的主要原因是慢性中耳炎(中耳炎)。在英国,每年大约有20万儿童反复遭受中耳感染。在发达国家,为对抗中耳炎而植入通气管是儿童手术的最常见原因,也是医疗保健服务的一个重大负担。鉴于受影响的个体数量和慢性OM的衰弱性质,更好地了解可能影响OM发病的因素是至关重要的。中耳间充质的异常存在与慢性中耳炎密切相关。在正常耳发育过程中,中耳的间充质组织丢失,形成一个充满空气的腔。在这项拨款中,我们希望研究为什么间充质在一些儿童的耳朵中保留,使用老鼠作为模型。我们将研究中耳腔通常是如何形成的,在没有移除间质的情况下会出现什么问题,然后尝试纠正这个缺陷。这项工作将有助于我们对中耳疾病的认识,并旨在开创新的治疗方法。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Abigail Tucker其他文献

Outcomes of Patients with Newly Diagnosed Multiple Myeloma Experiencing Treatment Failure after Upfront Quadruplet Therapy and Autologous Stem Cell Transplantationgayathri Ravi sup1/sup, Susan Bal sup1/sup, Kelly Godby sup1/sup, Smith Giri sup1/sup, Clare Ubersax sup1/sup, Abigail Tucker sup1/sup, Luciano J Costa sup1/sup
新诊断多发性骨髓瘤患者在初始四联疗法和自体干细胞移植后治疗失败的结果 gayathri Ravi 1 等,Susan Bal 1 等,Kelly Godby 1 等,Smith Giri 1 等,Clare Ubersax 1 等,Abigail Tucker 1 等,Luciano J Costa 1 等
  • DOI:
    10.1182/blood-2023-188272
  • 发表时间:
    2023-11-02
  • 期刊:
  • 影响因子:
    23.100
  • 作者:
    Gayathri Ravi;Susan Bal;Kelly Godby;Smith Giri;Clare Ubersax;Abigail Tucker;Luciano Costa
  • 通讯作者:
    Luciano Costa
06-P040 The role of Eda signalling in salivary gland development
  • DOI:
    10.1016/j.mod.2009.06.266
  • 发表时间:
    2009-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kirsty Wells;Denis Headon;Abigail Tucker
  • 通讯作者:
    Abigail Tucker
Feasibility and Accuracy of Bioelectric Impedance Analysis in Estimating Skeletal Muscle Mass in Older Adults with Multiple Myeloma
  • DOI:
    10.1182/blood-2024-201688
  • 发表时间:
    2024-11-05
  • 期刊:
  • 影响因子:
  • 作者:
    Apoorva Doshi;Abigail Tucker;Gayathri Ravi;Susan Bal;Kelly Godby;William Evans;Mahalakshmi Shubha Shankaran;Luciano J. Costa;Grant Williams;Smita Bhatia;Smith Giri
  • 通讯作者:
    Smith Giri
Functional Decline Among Older Adults with Multiple Myeloma Undergoing Autologous Hematopoetic Stem Cell Transplantation
  • DOI:
    10.1182/blood-2024-212176
  • 发表时间:
    2024-11-05
  • 期刊:
  • 影响因子:
  • 作者:
    Apoorva Doshi;Abigail Tucker;Clare Ubarsax;Gayathri Ravi;Grant Williams;Smith Giri
  • 通讯作者:
    Smith Giri
The cutting-edge of mammalian development; how the embryo makes teeth
哺乳动物发育的前沿;胚胎如何形成牙齿
  • DOI:
    10.1038/nrg1380
  • 发表时间:
    2004-07-01
  • 期刊:
  • 影响因子:
    52.000
  • 作者:
    Abigail Tucker;Paul Sharpe
  • 通讯作者:
    Paul Sharpe

Abigail Tucker的其他文献

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{{ truncateString('Abigail Tucker', 18)}}的其他基金

International Institutional Awards Tranche 2 Kings College
国际机构奖第二期国王学院
  • 批准号:
    BB/Z514585/1
  • 财政年份:
    2024
  • 资助金额:
    $ 52.74万
  • 项目类别:
    Research Grant
International Institutional Awards Tranche 1 Kings College
国际机构奖第一期国王学院
  • 批准号:
    BB/Y514159/1
  • 财政年份:
    2024
  • 资助金额:
    $ 52.74万
  • 项目类别:
    Research Grant
Understanding the mechanisms that control tooth replacement
了解控制牙齿更换的机制
  • 批准号:
    BB/W00240X/1
  • 财政年份:
    2022
  • 资助金额:
    $ 52.74万
  • 项目类别:
    Research Grant
Harnessing temporomandibular disc development to enhance regeneration
利用颞下颌盘发育来增强再生
  • 批准号:
    MR/V029568/1
  • 财政年份:
    2021
  • 资助金额:
    $ 52.74万
  • 项目类别:
    Research Grant
Analysis of the tissue and temporal specific role of Eya1 in ear development and its contribution to hearing loss
分析 Eya1 在耳朵发育中的组织和时间特异性作用及其对听力损失的贡献
  • 批准号:
    MR/R014515/1
  • 财政年份:
    2018
  • 资助金额:
    $ 52.74万
  • 项目类别:
    Research Grant
Understanding and enhancing repair of the tympanic membrane
了解和加强鼓膜修复
  • 批准号:
    MR/R023719/1
  • 财政年份:
    2018
  • 资助金额:
    $ 52.74万
  • 项目类别:
    Research Grant
Newton001: Salivary gland development and regeneration
Newton001:唾液腺发育和再生
  • 批准号:
    MR/M026426/1
  • 财政年份:
    2015
  • 资助金额:
    $ 52.74万
  • 项目类别:
    Research Grant
Genetics and morphology of the middle ear ossicles in the developing mouse embryo
发育中的小鼠胚胎中耳小骨的遗传学和形态学
  • 批准号:
    G0501037/1
  • 财政年份:
    2006
  • 资助金额:
    $ 52.74万
  • 项目类别:
    Research Grant

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