Study of hypothalamic amino acid sensing pathways implicated in the regulation of energy balance

能量平衡调节中涉及的下丘脑氨基酸传感通路的研究

• 批准号: MR/M501736/1
• 负责人: Clemence Blouet
• 金额: $ 53.22万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM501736%2F1
• 关键词: Study; hypothalamic; amino; acid; sensing

Obesity and its associated conditions, such as type 2 diabetes and cardiovascular disease, are major health threats worldwide. The brain plays a huge role in the regulation of energy balance. Specialized brain cells process information about ingested food and fat stores and directly regulate food intake, energy expenditure or storage. Among other signals of energy availability, the brain monitors circulating levels of nutrients such as glucose and amino acids. In this project we want to characterize the mechanisms implicated in brain amino acid detection in the regulation of energy balance. This research will improve our understanding of the pathways implicated in the regulation of body weight and potentially identify novel therapeutic targets for the treatment of obesity.

肥胖及其相关疾病，如2型糖尿病和心血管疾病，是全球主要的健康威胁。大脑在调节能量平衡方面发挥着重要作用。专门的脑细胞处理有关摄入的食物和脂肪储存的信息，并直接调节食物摄入，能量消耗或储存。在能量可用性的其他信号中，大脑监测营养物质（如葡萄糖和氨基酸）的循环水平。在这个项目中，我们希望表征涉及大脑氨基酸检测的能量平衡调节机制。这项研究将提高我们对体重调节途径的理解，并可能确定治疗肥胖的新治疗靶点。

项目成果

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

• DOI: 10.1101/110544
• 发表时间: 2017-02
• 期刊: eLife
• 影响因子: 7.7
• 作者: L. K. Burke;Tamana Darwish;Althea R. Cavanaugh;S. Virtue;Emma Roth;Joanna Morro;Shun-Mei Liu;Jing Xia;J. Dalley;K. Burling;S. Chua;Toni Vidal-Puig;G. Schwartz;C. Blouet

Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss.

肠促胰岛素和肠促胰岛素受体激动剂的大脑到达与食欲抑制和减肥相关的中心靶标。

• DOI: 10.17863/cam.106151
• 发表时间: 2024
• 作者: Buller S

Median eminence myelin continuously turns over in adult mice.

• DOI: 10.1016/j.molmet.2023.101690
• 发表时间: 2023-03
• 期刊: MOLECULAR METABOLISM
• 影响因子: 8.1
• 作者: Buller, Sophie;Kohnke, Sara;Hansford, Robert;Shimizu, Takahiro;Richardson, William D.;Blouet, Clemence
• 通讯作者: Blouet, Clemence

Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.

• DOI: 10.1016/j.molmet.2018.01.021
• 发表时间: 2018-04
• 期刊: Molecular metabolism
• 影响因子: 8.1
• 作者: Heeley N;Kirwan P;Darwish T;Arnaud M;Evans ML;Merkle FT;Reimann F;Gribble FM;Blouet C
• 通讯作者: Blouet C

Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy

GLP-1/CCK 联合疗法抑制进食作用的行为和神经化学机制

• DOI: 10.17863/cam.60058
• 发表时间: 2021
• 作者: Blouet C