Study of hypothalamic amino acid sensing pathways implicated in the regulation of energy balance

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Obesity and its associated conditions, such as type 2 diabetes and cardiovascular disease, are major health threats worldwide. The brain plays a huge role in the regulation of energy balance. Specialized brain cells process information about ingested food and fat stores and directly regulate food intake, energy expenditure or storage. Among other signals of energy availability, the brain monitors circulating levels of nutrients such as glucose and amino acids. In this project we want to characterize the mechanisms implicated in brain amino acid detection in the regulation of energy balance. This research will improve our understanding of the pathways implicated in the regulation of body weight and potentially identify novel therapeutic targets for the treatment of obesity.