Neuroanatomical and functional characterization of hindbrain leucine-sensing circuits implicated in the regulation of feeding behaviour

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After food ingestion, the brain receives information about the nutrient content of the meal and uses this information to regulate appetite and energy storage. We have identified specialized areas in the brain that can detect the amino acid L-leucine, a signal of protein intake, and suppress appetite in response to this signal. Our aim is to understand how the brain processes this signal and characterize the brain electrical connections that are turned on or off to regulate feeding. This research will increase our understanding of how the brain contributes to the regulation of appetite and body weight and could help develop new drugs for the prevention or treatment of obesity.