Neuroanatomical and functional characterization of hindbrain leucine-sensing circuits implicated in the regulation of feeding behaviour

与进食行为调节有关的后脑亮氨酸传感电路的神经解剖学和功能特征

• 批准号: MR/N003276/1
• 负责人: Clemence Blouet
• 金额: $ 51.29万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN003276%2F1
• 关键词: Neuroanatomical; functional; characterization; hindbrain; leucine

After food ingestion, the brain receives information about the nutrient content of the meal and uses this information to regulate appetite and energy storage. We have identified specialized areas in the brain that can detect the amino acid L-leucine, a signal of protein intake, and suppress appetite in response to this signal. Our aim is to understand how the brain processes this signal and characterize the brain electrical connections that are turned on or off to regulate feeding. This research will increase our understanding of how the brain contributes to the regulation of appetite and body weight and could help develop new drugs for the prevention or treatment of obesity.

食物摄入后，大脑接收有关膳食营养成分的信息，并使用这些信息来调节食欲和能量储存。我们已经确定了大脑中的专门区域，可以检测氨基酸L-亮氨酸，这是蛋白质摄入的信号，并抑制食欲以响应此信号。我们的目标是了解大脑如何处理这个信号，并描述大脑的电连接是打开还是关闭，以调节进食。这项研究将增加我们对大脑如何调节食欲和体重的理解，并有助于开发预防或治疗肥胖的新药。

项目成果

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

• DOI: 10.1101/110544
• 发表时间: 2017-02
• 期刊: eLife
• 影响因子: 7.7
• 作者: L. K. Burke;Tamana Darwish;Althea R. Cavanaugh;S. Virtue;Emma Roth;Joanna Morro;Shun-Mei Liu;Jing Xia;J. Dalley;K. Burling;S. Chua;Toni Vidal-Puig;G. Schwartz;C. Blouet

Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.

孤束核中的营养感应通过抑制 AgRP 神经元介导对进食的非厌恶性抑制。

• DOI: 10.17863/cam.57078
• 发表时间: 2020
• 作者: Tsang A