Characterisation of oligodendrocyte plasticity in the adult median eminence and its role in the regulation of energy balance

成人正中隆起少突胶质细胞可塑性特征及其在能量平衡调节中的作用

• 批准号: MR/S011552/1
• 负责人: Clemence Blouet
• 金额: $ 66.34万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS011552%2F1
• 关键词: Characterisation; oligodendrocyte; plasticity; adult; median

Oligodendrocytes are brain cells that isolate axons to allow fast transmission of electrical signals. They are formed during the first years of life in humans, but recent studies show that some continue to be formed in adulthood in response to environmental challenges, for example during the acquisition of new motor skills. We found that nutritional signals regulate the formation of new oligodendrocytes in adults in a region of the brain that controls appetite and weight gain. Our aim is to determine how these new cells contribute to the regulation of appetite and the maintenance of body weight, and whether this process is impaired in obesity. This research will increase our understanding of how nutrition regulates 1-the formation of new oligodendrocytes in adults, and 2- brain pathways controlling appetite and body weight. Potential applications include new therapeutic strategies for the treatment of obesity and demyelinating diseases like multiple sclerosis.

少突胶质细胞是一种分离轴突以实现电信号快速传输的脑细胞。它们是在人类生命的最初几年形成的，但最近的研究表明，有些在成年后继续形成，以应对环境挑战，例如在获得新的运动技能期间。我们发现，在成年人大脑中控制食欲和体重增加的区域，营养信号调节新少突胶质细胞的形成。我们的目标是确定这些新细胞是如何参与食欲调节和体重维持的，以及这一过程是否在肥胖中受到损害。这项研究将增加我们对营养如何调节1-成人新少突胶质细胞的形成和2-控制食欲和体重的脑通路的理解。潜在的应用包括治疗肥胖和脱髓鞘疾病（如多发性硬化症）的新治疗策略。

项目成果

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.

• DOI: 10.1016/j.celrep.2021.109362
• 发表时间: 2021-07-13
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Kohnke S;Buller S;Nuzzaci D;Ridley K;Lam B;Pivonkova H;Bentsen MA;Alonge KM;Zhao C;Tadross J;Holmqvist S;Shimizu T;Hathaway H;Li H;Macklin W;Schwartz MW;Richardson WD;Yeo GSH;Franklin RJM;Karadottir RT;Rowitch DH;Blouet C
• 通讯作者: Blouet C

Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss.

肠促胰岛素和肠促胰岛素受体激动剂的大脑到达与食欲抑制和减肥相关的中心靶标。

• DOI: 10.17863/cam.106151
• 发表时间: 2024
• 作者: Buller S

Median eminence myelin continuously turns over in adult mice.

• DOI: 10.1016/j.molmet.2023.101690
• 发表时间: 2023-03
• 期刊: MOLECULAR METABOLISM
• 影响因子: 8.1
• 作者: Buller, Sophie;Kohnke, Sara;Hansford, Robert;Shimizu, Takahiro;Richardson, William D.;Blouet, Clemence
• 通讯作者: Blouet, Clemence