Construction of an Imaging Centre of Excellence (ICE) at the new South Glasgow University Hospital

在新的南格拉斯哥大学医院建设卓越影像中心 (ICE)

• 批准号: MR/N003403/1
• 负责人: Anna Dominiczak
• 金额: $ 2038.72万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN003403%2F1
• 关键词: Construction; Imaging; Centre; Excellence; ICE

The synergy between imaging and genomics technologies has been recognised as being an important driver to the future development of Stratified or Precision Medicine. The benefits of stratified medicine are now globally recognised, and Scotland is uniquely placed to capitalise on this potential, owing to its strong academic research base, advanced electronic health records within the NHS, and a strong industry presence in genomics, bioinformatics and diagnostics. The South Glasgow University Hospital represents an investment to Glasgow and Scotland in the region of £1Billion. When it opens in 2015, the new hospital will be the largest in Western Europe and will include maternity, paediatric and adult services on a single site. The Imagine Centre of Excellence (ICE), located at the new hospital, will uniquely accommodate a 7 Tesla MRI scanner together with other imaging modalities for clinical and research use, including 3T MRI and high resolution multi-slice CT, all networked and sharing staff with the large number of service scanners within the main hospital. This state-of-the-art equipment will be housed alongside clinical academic imaging specialists, NHS clinical physics expertise, innovation space for industry, and potential for expansion of precision medicine activities.The University of Glasgow led the development of the Scotland-wide £20M Stratified Medicine Scotland Innovation Centre (SMS-IC), which will be based adjacent to the ICE building. The co-location of ICE and SMS-IC will therefore provide significant added value to both centres.The creation of an internationally competitive centre in medical imaging incorporating NHS, academic and industry partners will allow Glasgow to support a much greater volume and variety of clinical trials and translational development than currently, including the associated supply chain. The facility will be co-located alongside commercial, learning, research and clinical facilities, and will be accessible to industry partners and collaborators thus ensuring spin off benefits to the local Scottish company base of specialist CROs and other service providers.The proposed facility will maximise and facilitate the economic impact from the clinical research excellence at the new South Glasgow University Hospital, and ensure the hospital site becomes a clinical research-driven UK exemplar of a Life Sciences cluster. As such, the proposal fully aligns with the Scottish Life Sciences Strategy and the facility will add significant value to existing assets in Scotland.

成像和基因组学技术之间的协同作用被认为是分层或精准医学未来发展的重要驱动力。分层医学的好处现在是全球公认的，苏格兰是独一无二的，以利用这一潜力，由于其强大的学术研究基础，先进的电子健康记录在国民保健服务，以及强大的行业存在基因组学，生物信息学和诊断。南格拉斯哥大学医院代表着对格拉斯哥和苏格兰的110亿英镑的投资。新医院将于2015年开业，届时将成为西欧最大的医院，并将在一个地点提供产科、儿科和成人服务。Imagine Centre of Excellence（ICE）位于新医院，将专门容纳一台7特斯拉MRI扫描仪以及其他用于临床和研究的成像设备，包括3 T MRI和高分辨率多层CT，所有设备都与主医院内的大量服务扫描仪联网并共享工作人员。这些先进的设备将与临床学术成像专家、NHS临床物理专业知识、行业创新空间以及精准医疗活动的扩展潜力一起安置。格拉斯哥大学领导了苏格兰范围内耗资2000万英镑的苏格兰分层医学创新中心（SMS-IC）的开发，该中心将位于ICE大楼附近。ICE和SMS-IC的共同定位将为两个中心提供显著的附加值。创建一个具有国际竞争力的医学成像中心，包括NHS，学术和行业合作伙伴，将使格拉斯哥能够支持比目前更多的临床试验和转化开发，包括相关的供应链。该设施将与商业、学习、研究和临床设施位于同一地点，并将面向行业合作伙伴和合作者，从而确保为苏格兰当地的专业CRO和其他服务提供商带来附带利益。拟建设施将最大限度地发挥和促进新南格拉斯哥大学医院卓越临床研究的经济影响，并确保该医院成为临床研究驱动的英国生命科学集群的典范。因此，该提案完全符合苏格兰生命科学战略，该设施将为苏格兰现有资产增加重大价值。

项目成果

Effect of digoxin in patients with heart failure and mid-range (borderline) left ventricular ejection fraction

• DOI: 10.1002/ejhf.1160
• 发表时间: 2018-07-01
• 期刊: EUROPEAN JOURNAL OF HEART FAILURE
• 影响因子: 18.2
• 作者: Abdul-Rahim, Azmil H.;Shen, Li;McMurray, John J. V.
• 通讯作者: McMurray, John J. V.

National Institutes of Health Stroke Scale Item Profiles as Predictor of Patient Outcome External Validation on Independent Trial Data

• DOI: 10.1161/strokeaha.114.006837
• 发表时间: 2015-02-01
• 期刊: STROKE
• 影响因子: 8.3
• 作者: Abdul-Rahim, Azmil H.;Fulton, Rachael L.;Lees, Kennedy R.
• 通讯作者: Lees, Kennedy R.

Association of improved outcome in acute ischaemic stroke patients with atrial fibrillation who receive early antithrombotic therapy: analysis from VISTA

• DOI: 10.1111/ene.12577
• 发表时间: 2015-07-01
• 期刊: EUROPEAN JOURNAL OF NEUROLOGY
• 影响因子: 5.1
• 作者: Abdul-Rahim, A. H.;Fulton, R. L.;Lees, K. R.
• 通讯作者: Lees, K. R.

The relationship between adiposity, bone density and microarchitecture is maintained in young women irrespective of diabetes status

• DOI: 10.1111/cen.13410
• 发表时间: 2017-10-01
• 期刊: CLINICAL ENDOCRINOLOGY
• 影响因子: 3.2
• 作者: Abdalrahaman, N.;McComb, C.;Ahmed, S. F.
• 通讯作者: Ahmed, S. F.

Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: analysis of the CHARM-Preserved and I-Preserve trials.

• DOI: 10.1093/eurheartj/ehw509
• 发表时间: 2017-03-07
• 期刊: European heart journal
• 影响因子: 39.3
• 作者: Abdul-Rahim AH;Perez AC;MacIsaac RL;Jhund PS;Claggett BL;Carson PE;Komajda M;McKelvie RS;Zile MR;Swedberg K;Yusuf S;Pfeffer MA;Solomon SD;Lip GYH;Lees KR;McMurray JJV;Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Preserved (CHARM-Preserved) and the Irbesartan in Heart Failure with Preserved Systolic Function (I-Preserve) Steering Committees
• 通讯作者: Candesartan in Heart failure Assessment of Reduction in Mortality and Morbidity-Preserved (CHARM-Preserved) and the Irbesartan in Heart Failure with Preserved Systolic Function (I-Preserve) Steering Committees