BRAIN ACTIVITY MAPS INTEGRATING FMRI, EEG AND MEG

描述（改编自申请人摘要）：神经系统评估依赖于两大类技术：（1）结构和血液动力学/代谢过程的断层扫描重建;（2）电磁场记录。这些技术具有互补的敏感性。使用功能性磁共振成像（fMRI）的脑活动的血流动力学评估在时间上受限于血流动力学响应的潜伏期（约1秒），但是可以提供毫米空间采样。脑电图（EEG）和脑磁图（MEG）提供小于1毫秒的时间分辨率，但它们对多个源的空间分辨率是模糊和有限的。申请人已经开发了一种将MEG与fMRI和结构MRI相结合以获得动态人脑活动的高分辨率时空图的方法。我们建议在这里扩展这种方法，包括脑电图，一个更便宜，更广泛的可用性和临床验证的替代MEG。将在模拟研究中以及通过与人类颅内记录的直接比较来完善和测试集成方法。因此，目前研究的最终目标是验证和扩展一种有效的方法，将用于神经诊断的主导技术结合起来。预计这种方法将在癫痫灶的术前规划和保留在择期神经外科执行基本功能的皮层的本地化的应用。拟议的商业应用：神经精神诊断和科学软件。

DESCRIPTION (Adapted from applicant's abstract): Neurological assessment relies on two main categories of technology: (1) tomographic reconstruction of structure and hemodynamic/metabolic processes; and (2) recordings of electromagnetic fields. These technologies have complementary sensitivities. Hemodynamic assessment of brain activity using functional magnetic resonance imaging (fMRI) is temporally limited by the latency of the hemodynamic response, about 1 second, but can provide millimeter spatial sampling. Electroencephalography (EEG) and magnetoencephalography (MEG) provide temporal resolution of less than 1 millisecond, but their spatial resolution for multiple sources is ambiguous and limited. The applicants have developed a method that combines MEG with fMRI and structural MRI to obtain high-resolution spatiotemporal maps of dynamic human brain activity. We propose here to extend this method to include EEG, a less expensive, more widely available and clinically validated alternative to MEG. The integrated method will be refined and tested in simulation studies as well as by direct comparison with intracranial recordings in humans. Thus, the ultimate goal of the current research is to validate and extend an effective method that unites the dominant technologies used for neurological diagnosis. It is anticipated that this method will have applications in the localization of epileptic foci for presurgical planning and the sparing of cortex performing essential functions in elective neurosurgery. PROPOSED COMMERCIAL APPLICATION: Neuropsychiatric diagnosis and scientific software.