PATH MODEL FOR HIPPOCAMPAL NEOCORTICAL INTERACTIONS IN MEMORY & EPILEPSY

要开始对基因的分析，需要一笔启动资金 编码新近发现的核仁蛋白BN46151(Trimbur& J.细胞科学(J.Cell Sci).103：167；Trimbur&Walsh，1993，J.Cell 比奥尔。122：753)。BN46151的不同寻常之处在于它似乎与 微管。当前的项目旨在描述 这种蛋白质的结构和功能。我们目前正在进行测序 对BN46151进行编码的克隆，我们需要请求的计算机 分析和组装这些序列的资源。一旦完成 BN46151基因序列已公布，将用于开发 利用Vitlo中表达的重组蛋白进行功能分析 在活体内。

A starter grant is requested to begin the analysis of the gene encoding the recently discovered nucleolar protein BN46151 (Trimbur & Walsh, 1992, J. Cell Sci. 103: 167; Trimbur & Walsh, 1993, J. Cell Biol. 122: 753). BN46151 is unusual in that it appears to bind to microtubules. The current project is directed at characterizing the structure and function of this protein. We are currently sequencing clones that encode BN46151 and we need the requested computer resources to analyze and assemble these sequences. Once the complete sequence of the BN46151 gene is available, it will be used to develop functional analyses using recombinant proteins expressed both in vitlo and in vivo.