ONLINE 2D FUNCTIONAL PROTEOMICS

在线二维功能蛋白质组学

• 批准号: 2865578
• 负责人: Babak Esmaeli-Azad
• 金额: $ 10万
• 依托单位: BIOARRAY TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-10 至 1999-11-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2865578
• 关键词: Internet; biomedical equipment development; cadmium; gel electrophoresis; protein sequence; protein structure function; radiation detector; tellurium; zinc

DESCRIPTION: (adapted from applicant's abstract) The goal of the proposed research is to develop an ultrasensitive online detector system for application to proteomics and protein separation by 2-D gel analysis. Applied to 2-D analysis, this system makes comprehensive cartography of proteins of all abundance levels in an organism, cell or tissue possible. This online detector system permits thorough and rapid investigation of functional aspects of cancer. Multi-color cartography of proteomics permits accurate protein differential display leading to functional analysis of cancer related paradigms and model systems. Bioinformatics generated from such cartography can lead to the development of gene product information databases with valuable utility for scientific experimental design and analysis for all aspects of cancer biology. This type of information is necessary for the full understanding of the function of proteins involved in development of cancer. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：（改编自申请人的摘要） 研究开发一种超灵敏的在线检测系统， 蛋白质组学和通过二维凝胶分析的蛋白质分离。适用于2-D 分析，该系统使所有蛋白质的全面制图 在生物体、细胞或组织中的丰度水平是可能的。这个在线探测器 系统允许彻底和快速调查的功能方面， 癌蛋白质组学的多色制图允许准确的蛋白质 差异显示导致癌症相关范例的功能分析 和模型系统。从这种制图产生的生物信息学可以导致 基因产物信息数据库的开发， 科学的实验设计和分析癌症生物学的各个方面。 这种类型的信息是必要的充分了解 参与癌症发展的蛋白质的功能。 拟议商业应用：不可用