ONLINE 2D FUNCTIONAL PROTEOMICS

描述：(改编自申请人的摘要)建议的目标 研究内容是开发一种超灵敏的在线检测系统，以供应用 对蛋白质组学和蛋白质二维凝胶分析进行分析。应用于二维 分析，该系统对所有蛋白质进行了全面的绘制 有机体、细胞或组织中可能存在的丰度水平。这个在线检测器 系统允许对功能方面进行彻底和快速的调查 癌症。蛋白质组学的多色地图绘制允许精确的蛋白质 差异显示导致癌症相关范例的功能分析 和模型系统。由这种制图产生的生物信息学可以导致 具有实用价值的基因产品信息数据库的开发 癌症生物学方方面面的科学实验设计和分析。 这种类型的信息对于充分理解 参与癌症发展的蛋白质的功能。 建议的商业应用：不可用

DESCRIPTION: (adapted from applicant's abstract) The goal of the proposed research is to develop an ultrasensitive online detector system for application to proteomics and protein separation by 2-D gel analysis. Applied to 2-D analysis, this system makes comprehensive cartography of proteins of all abundance levels in an organism, cell or tissue possible. This online detector system permits thorough and rapid investigation of functional aspects of cancer. Multi-color cartography of proteomics permits accurate protein differential display leading to functional analysis of cancer related paradigms and model systems. Bioinformatics generated from such cartography can lead to the development of gene product information databases with valuable utility for scientific experimental design and analysis for all aspects of cancer biology. This type of information is necessary for the full understanding of the function of proteins involved in development of cancer. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE