MRC Centre for Neurodevelopmental Disorders
MRC 神经发育障碍中心
基本信息
- 批准号:MR/N026063/1
- 负责人:
- 金额:$ 187.02万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2016
- 资助国家:英国
- 起止时间:2016 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Neurodevelopmental disorders are a group of disorders in which the development of the brain is disturbed. This can manifest as neuropsychiatric problems or impaired motor function, learning, language or non-verbal communication. These disorders include epilepsy, intellectual disability, autism, and even other diseases with a relatively late onset, such as schizophrenia. These disorders are very difficult to treat and often cause a life-long disability. The development of the brain is a highly orchestrated process, controlled by genetic information under very clear influence from the environment. In humans, brain development prolongs from early in life to adolescence, when many connections between neurons, the cells of the brain, are actively remodelled. Any deviation from this very protracted program can result in neurodevelopmental disorders and, depending on specific timing, might lead to distinct pathology later in life.Neurodevelopmental disorders have a prominent genetic basis, although this does not necessarily mean that they are hereditary. For instance, many patients carry de novo mutations - an alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell (egg or sperm) of one of the parents or in the fertilized egg itself. Recent advances in human genetics have identified specific mutations with these disorders. Unfortunately, we still do not understand how these mutations and concomitant environmental insults cause neurodevelopmental disorders. Our vision is to build a world-class Centre at King's College London with research programmes that will transform our understanding of the origin of neurodevelopmental disorders. To this end, we will investigate the biological mechanisms underlying these disorders in human patients and animal models. We will also train and nurture the next generation of scientific leaders in the field, equipped to dissolve the boundaries that exist between basic research and clinical disciplines.In the long term, we aim to translate the new knowledge into clinical advances that change the lives of affected individuals and their families, in collaboration with industrial partners, other research centres and patient associations.
神经发育障碍是一组大脑发育受到干扰的障碍。这可能表现为神经精神问题或运动功能受损,学习,语言或非语言交流。这些疾病包括癫痫、智力残疾、自闭症,甚至其他相对较晚发病的疾病,如精神分裂症。这些疾病很难治疗,往往会导致终身残疾。大脑的发育是一个高度协调的过程,由遗传信息控制,并受到环境的明显影响。在人类中,大脑的发育从生命的早期一直延续到青春期,此时神经元(大脑细胞)之间的许多连接都在积极重塑。任何偏离这个非常漫长的程序都可能导致神经发育障碍,并且根据特定的时间,可能导致生命后期的独特病理学。神经发育障碍具有突出的遗传基础,尽管这并不一定意味着它们是遗传性的。例如,许多患者携带新生突变-由于父母之一的生殖细胞(卵子或精子)或受精卵本身的突变,一个家庭成员中首次出现的基因改变。人类遗传学的最新进展已经确定了这些疾病的特定突变。不幸的是,我们仍然不知道这些突变和伴随的环境损伤如何导致神经发育障碍。我们的愿景是在伦敦国王学院建立一个世界级的中心,其研究项目将改变我们对神经发育障碍起源的理解。为此,我们将在人类患者和动物模型中研究这些疾病的生物学机制。我们还将培训和培养该领域的下一代科学领导者,以消除基础研究和临床学科之间存在的界限。从长远来看,我们的目标是将新知识转化为临床进步,改变受影响的个人及其家庭的生活,与工业合作伙伴,其他研究中心和患者协会合作。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A Three-Layer Network Model of Direction Selective Circuits in the Optic Tectum.
- DOI:10.3389/fncir.2017.00088
- 发表时间:2017
- 期刊:
- 影响因子:3.5
- 作者:Abbas F;Triplett MA;Goodhill GJ;Meyer MP
- 通讯作者:Meyer MP
Preliminary evidence for neural responsiveness to infants in mothers with schizophrenia and the implications for healthy parenting.
精神分裂症母亲对婴儿的神经反应的初步证据及其对健康育儿的影响。
- DOI:10.1016/j.schres.2017.11.033
- 发表时间:2018
- 期刊:
- 影响因子:4.5
- 作者:Abel KM
- 通讯作者:Abel KM
Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals
- DOI:10.1101/349415
- 发表时间:2018-06
- 期刊:
- 影响因子:0
- 作者:Dwaipayan Adhya;V. Swarup;R. Nagy;L. Dutan;C. Shum;K. Jozwik;M. Mendez;J. Horder;P. Nowosiad;Irene O. Lee;D. Skuse;E. Loth;D. Howley;F. Flinter;D. Murphy;G. McAlonan;D. Geschwind;J. Price;J. Carroll;D. Srivastava;S. Baron-Cohen
- 通讯作者:Dwaipayan Adhya;V. Swarup;R. Nagy;L. Dutan;C. Shum;K. Jozwik;M. Mendez;J. Horder;P. Nowosiad;Irene O. Lee;D. Skuse;E. Loth;D. Howley;F. Flinter;D. Murphy;G. McAlonan;D. Geschwind;J. Price;J. Carroll;D. Srivastava;S. Baron-Cohen
The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand Dependent.
- DOI:10.1523/eneuro.0272-17.2017
- 发表时间:2017-09
- 期刊:
- 影响因子:3.4
- 作者:Acharya KD;Nettles SA;Sellers KJ;Im DD;Harling M;Pattanayak C;Vardar-Ulu D;Lichti CF;Huang S;Edwards DP;Srivastava DP;Denner L;Tetel MJ
- 通讯作者:Tetel MJ
Understanding the role of steroids in typical and atypical brain development: Advantages of using a "brain in a dish" approach.
- DOI:10.1111/jne.12547
- 发表时间:2018-03
- 期刊:
- 影响因子:3.2
- 作者:Adhya D;Annuario E;Lancaster MA;Price J;Baron-Cohen S;Srivastava DP
- 通讯作者:Srivastava DP
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Oscar Marin其他文献
グリアとの相互作用による新生ニューロンの 移動制御と傷害脳の再生過程の解析
与胶质细胞相互作用控制新神经元迁移及损伤脑再生过程分析
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
金子奈穂子;Oscar Marin;小池正人;廣田ゆき;内山安男;Jane Y Wu;Qiang Lu;Marc Tessier-Lavigne;Arturo Alvarez-Buylla;岡野栄之;John L.R.Rubenstein;澤本和延 - 通讯作者:
澤本和延
Slit-Robo signaling regulates migration of neurons under physiological and pathological conditions.
Slit-Robo 信号传导在生理和病理条件下调节神经元的迁移。
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
Naoko Kaneko;Oscar Marin;Koike;Yuki Hirota;Fujio Murakami;Jane Wu;Yasuop Uchiama;Marc Tessier-Lavigne;Arturo Alvarez-Buylla;Hideyuki Okano;John L.R Rubenstein;Kazunobu Sawamoto - 通讯作者:
Kazunobu Sawamoto
Dynamic interaction of migrating neurons with glial cells in adult brain. (グリア細胞との相互作用による新生ニューロンの移動制御機構) (第2回 Young Investigator's Award受賞講演)
成人大脑中迁移神经元与神经胶质细胞的动态相互作用(第二届青年研究员颁奖典礼)
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
金子奈穂子;Oscar Marin;小池正人;廣田ゆき;内山安男;Jane Y Wu;Qiang Lu;Marc Tessier-Lavigne;Arturo Alvarez-Buylla;岡野栄之;John L.R.Rubenstein;澤本和延 - 通讯作者:
澤本和延
Biodegradable microsphere mediated perforation of cells using femtosecond laser for theranos- tics
使用飞秒激光进行可生物降解的微球介导的细胞穿孔用于治疗诊断
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Naoko Kaneko;Oscar Marin;Masato Koike;Yuki Hirota;Yasuo Uchiyama;Jane Y Wu;Qiang Lu;Marc Tessier-Lavigne;Arturo Alvarez-Buylla;Hideyuki Okano;John L.R.Rubenstein;Kazunobu Sawamoto;上林清孝;山田勇磨;寺川光洋 - 通讯作者:
寺川光洋
グリアとの相互作用による新生ニューロンの移動制御と傷害脳の再生過程の解析(名古屋市立大学医学会賞受賞記念講演)
通过与神经胶质细胞相互作用控制新神经元迁移以及分析受伤大脑的再生过程(名古屋市立大学医学会奖纪念演讲)
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
金子奈穂子;Oscar Marin;小池正人;廣田ゆき;内山安男;Jane Y Wu;Qiang Lu;Marc Tessier-Lavigne;Arturo Alvarez-Buylla;岡野栄之;John L.R.Rubenstein;澤本和延;金子奈穂子 - 通讯作者:
金子奈穂子
Oscar Marin的其他文献
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{{ truncateString('Oscar Marin', 18)}}的其他基金
Functional Genomics of Human Brain Development Cluster
人脑发育集群的功能基因组学
- 批准号:
MR/Y031016/1 - 财政年份:2024
- 资助金额:
$ 187.02万 - 项目类别:
Research Grant
Role of VGF in cortical PV+ interneuron interconnectivity
VGF 在皮质 PV 中间神经元互连中的作用
- 批准号:
BB/Y001958/1 - 财政年份:2023
- 资助金额:
$ 187.02万 - 项目类别:
Research Grant
MRC Centre for Neurodevelopmental Disorders
MRC 神经发育障碍中心
- 批准号:
MR/W006251/1 - 财政年份:2021
- 资助金额:
$ 187.02万 - 项目类别:
Research Grant
Understanding the contribution of cortical interneuron dysfunction to schizophrenia
了解皮质中间神经元功能障碍对精神分裂症的影响
- 批准号:
MR/S010785/1 - 财政年份:2019
- 资助金额:
$ 187.02万 - 项目类别:
Research Grant
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