Selenium in early life to enhance neurodevelopment in unfavourable settings (SELENIUS)

生命早期的硒可增强不利环境中的神经发育（SELENIUS）

• 批准号: MR/N029860/1
• 负责人: Susan Jane Fairweather-Tait
• 金额: $ 2.63万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN029860%2F1
• 关键词: Selenium; early; life; enhance; neurodevelopment

The proposal aims at evaluating the specific role of selenium (Se) in relation to other nutrients and trace elements in favouring brain and behavioural plasticity. The central hypothesis we will test is the role of oxidative stress and inflammation as key processes connecting diet, peripheral tissues and brain development. Two isocaloric diets differing in Se content will be given to pregnant and lactating female rats and to their offspring till adulthood. The role of Se in supporting brain and behaviour development will be also assessed in presence of lead (Pb) an environmental stressor able to affect cognitive development that is a concern in some European countries. The project has been organized in 5 work packages aimed at dissecting the effects of the different diets on behavioural development, cognitive functions, hippocampal synaptic plasticity and peripheral and central inflammation, using. ex vivo and in vitro approaches and transcriptomic, proteomic, metabolomics/lipidomic, measurement of oxidative stress and inflammatory pathways in different target organs. The offspring of the two sexes at different ages will be separately considered to emphasize sex-differences in neurodevelopment. The experimental studies will be reinforced by the observation obtained from an ongoing EU human birth cohort where exposure to Pb, micronutrients, lifestyle have been measured in children in association with assessment of cognitive, language and motor development.

该建议旨在评估硒(Se)与其他营养素和微量元素在促进大脑和行为可塑性方面的具体作用。我们将测试的中心假设是氧化应激和炎症作为连接饮食、外围组织和大脑发育的关键过程所起的作用。怀孕和哺乳的雌性大鼠及其后代将接受两种不同Se含量的等卡路里饮食，直到成年。还将在铅(铅)存在的情况下评估硒在支持大脑和行为发育方面的作用，铅是一种环境应激源，可能会影响认知发展，这在一些欧洲国家是一个令人担忧的问题。该项目已被组织成5个工作包，旨在剖析不同饮食对行为发育、认知功能、海马区突触可塑性以及外周和中枢炎症的影响。体外和体外方法以及转录学、蛋白质组学、代谢组学/脂体学、不同目标器官中氧化应激和炎症途径的测量。不同年龄的两性后代将被单独考虑，以强调神经发育的性别差异。从正在进行的欧盟人类出生队列中获得的观察结果将加强实验研究，在评估认知、语言和运动发育的同时，对儿童暴露于铅、微量营养素、生活方式进行了测量。