CONSTRUCTION OF EXTRAMURAL RESEARCH FACILITIES

校外研究设施建设

基本信息

批准号：
6039598
负责人：
Gerald D Fischbach
金额：
$ 100万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-30 至 2002-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6039598
关键词：
biomedical facility building /facility design /renovation cardiovascular disorder

项目摘要

We are requesting funds for major alterations and renovations of existing research space at the College of Physicians & Surgeons of Columbia University for the purposes of conducting basic and translational research in the field of vascular diseases. The College has recently established a Center for Vascular Biology in recognition of the importance of vascular diseases to our patient population, to exploit recent advances in the understanding of mechanisms underlying vascular disease, and to recognize the enormous opportunities for basic and translational research that have resulted. The Dean has identified a highly integrated team of first-rate investigators to serve as core faculty for the vascular biology effort, and seeks to establish a physical environment of 5,000 square feet of laboratory space supportive of the special programmatic requirements of this new research initiative in our Medical Center. The core group of four investigators represents the Departments of Surgery, Pathology, Center. The core group of four investigators represents the Departments of Surgery, Pathology, Medicine, and Physiology & Cellular Biophysics, and forms the nucleus for a large collaborative group drawn from the Departments of Anesthesiology, Neurological Surgery, Pediatrics, Pharmacology, Radiology, and the School of Dental and Oral Surgery. The Center will target four key thematic areas in vascular biology including diabetic vascular dysfunction, cerebrovascular disease, reperfusion injury and the biology of thrombosis. This program already accounts for approximately $1.3 million in annual direct costs from NIH (further direct costs from the Juvenile Diabetes Foundation and Heart Association are approximately $571,350/year), in addition to approximately $1.02 million/year in pending Federal grants. The larger collaborative group of investigators accounts for approximately $4.8 million in annual direct costs on Federal grants. Exciting observations have emanated from the core group of investigators, including new insights into mechanisms underlying diabetic vascular disease, cerebral ischemic and amyloid angiopathy, and the biology of thrombosis. Core members of the Center for Vascular Biology are now working in non- contiguous places within the University, using space designed for research activities quite distinct from those required for their collaborative research program in Vascular Biology. The proposed changes in the research environment will facilitate our ability to upgrade, consolidate and modernize the physical plant into efficiently designed and operational laboratories with specialized shared core facilities and laboratory modules. This will result in more effective use of our laboratory space, and will allow us to efficiently perform studies which can only be done with considerable difficulty at the present time. These facilities will be used exclusively for the purposes related to the research as outlined by the specific aim of our federal and non-federal grant proposals, and the research training (teaching) of pre-doctoral and postdoctoral fellows for at least the next 20 years.

我们正在向哥伦比亚大学医师与外科医生学院现有研究空间进行重大改动和翻新资金，目的是在血管疾病领域进行基本和转化研究。该学院最近建立了一个血管生物学中心，以认识到血管疾病对我们的患者人群的重要性，以利用对血管疾病潜在机制的理解的最新进展，并认识到产生的基本和翻译研究的巨大机会。该院长已经确定了一支高度综合的一流调查人员团队，以作为血管生物学工作的核心教师，并试图建立5,000平方英尺的实验室空间的物理环境，以支持我们医疗中心这项新研究计划的特殊程序性要求。四个研究人员的核心组代表手术，病理，中心的部门。四个研究人员的核心组代表了手术，病理学，医学和生理学和细胞生物物理学的部门，并为来自麻醉，神经学手术，儿科，药理学，放射学，牙科和口腔外科学院的大型协作组形成了核心。该中心将针对血管生物学的四个关键主题领域，包括糖尿病血管功能障碍，脑血管疾病，再灌注损伤和血栓形成生物学。该计划的年度直接费用约为130万美元（少年糖尿病基金会和心脏协会的进一步直接费用约为571,350美元/年），除了大约102万美元/年的联邦赠款。较大的合作研究人员小组的联邦赠款年度直接成本约为480万美元。令人兴奋的观察结果是从研究人员组中得出的，包括对糖尿病血管疾病，脑缺血性和淀粉样血管病的基本机制的新见解，以及血栓形成的生物学。血管生物学中心的核心成员现在正在大学内的非连续场所工作，使用用于研究活动的空间，与其血管生物学协作研究计划所需的空间相关。拟议的研究环境变化将有助于我们升级，合并和现代化物理工厂的能力，以有效设计和运营实验室，并具有专门的共享核心设施和实验室模块。这将导致更有效地利用我们的实验室空间，并使我们能够有效地进行研究，而目前只能在很大程度上进行。这些设施将专门用于与我们的联邦和非联邦赠款建议的具体目的以及至少在接下来的20年中的研究培训（教学）的研究（教学）。