INSTITUTE FOR CANCER GENETICS ON TWO FLOORS

两层楼的癌症遗传学研究所

• 批准号: 6707364
• 负责人: Gerald D Fischbach
• 金额: $ 360万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6707364
• 关键词: biomedical facility; brain neoplasms; breast neoplasms; building /facility design /renovation; lymphoma; neoplasm /cancer diagnosis; neoplasm /cancer genetics; neoplasm /cancer therapy; proteomics; university

DESCRIPTION (provided by applicant): We are requesting funds for construction of research space to house the Institute for Cancer Genetics (ICG), a critical component of Columbia University devoted to basic and translational research on human cancer. The space would occupy the 8th and 9th floors of the new Irving Cancer Research Center. The core and shell construction of this building is underway and will be completed by mid 2003. The ICG was established in 1999 as a University Institute devoted to research and teaching on human cancer. The ICG's mission is to elucidate the pathogenesis of cancer and identify targets for diagnosis and treatment of malignant disease, and as such to serve as the main research arm of the Herbert Irving Comprehensive Cancer Center. Dr. Dalla-Favera was named ICG Director and assigned the task of forming the Institute faculty. In less than four years the ICG has grown to include 9 primary research laboratories led by faculty members with appointments in 5 different clinical or basic science Departments. The research activities of the ICG are organized into four programmatic areas: lymphoid neoplasia, breast cancer, brain tumors, and mechanisms of genomic stability. These Programs were chosen to optimize the impact of ICG research in the battle against cancer and to exploit existing areas of strength in other fields of biomedicine at Columbia. As such, each of the four ICG Programs seeks to develop a fertile research environment and the critical mass necessary to achieve significant scientific advances. By any measure, the ICG has been immensely successful in both its research and teaching activities. This is manifested in its increasing funding base from peer-reviewed grants, which has grown from ~$1.5 million in June 1999 to ~$5.4 million of currently approved funds (annual direct costs), including nine Ro1 grants, a P01 Program Project grant, and a Cancer Biology Training grant. When the ICG was established in 1999, it was assigned to ~15,500 square feet of swing space in the Russ Berrie Science Pavilion. This was intended to be a temporary arrangement until the ICG was moved to its permanent home in the future Irving Cancer Research Center. The proposed relocation of the ICG to this site will provide multiple b for existing ICG laboratories that have grown in personnel and funding; ii) the recruitment of two new faculty necessary for completion of the ICG research program; and iii) laboratory space to host state-of-the-art core facilities available to all Columbia University investigators (i.e., Genomics, Proteomics, Cytogenetics, and Pathology). Finally, relocation of the ICG to the proposed facility represents a crucial first step in the consolidation of cancer research activities at Columbia in a single dedicated building, the Irving Institute of Cancer Research. These facilities will be used exclusively for purposes related to the research outlined in the specific aims of our federal and non-federal grant proposals and for the research training/teaching of predoctoral and postdoctoral fellows for at least the next 20 Years.

描述（由申请人提供）： 我们要求建造研究空间的资金来容纳癌症遗传学研究所（ICG），这是哥伦比亚大学的关键组成部分，致力于人类癌症的基础和转化研究。 该空间将占据新的欧文癌症研究中心的8层和9层。 该建筑物的核心和外壳建设正在进行中，并将在2003年中期完成。ICG成立于1999年，是一家专门研究人类癌症的大学学院。 ICG的任务是阐明癌症的发病机理，并确定诊断和治疗恶性疾病的靶标，因此是赫伯特·欧文（Herbert Irving）综合癌症中心的主要研究部门。 Dalla-Favera博士被任命为ICG主任，并分配了组建研究所教师的任务。在不到四年的时间里，ICG成长为包括由教职员工领导的9个主要研究实验室，并在5个不同的临床或基础科学部门任命。 ICG的研究活动分为四个程序化领域：淋巴性肿瘤，乳腺癌，脑肿瘤和基因组稳定性机制。 选择这些计划是为了优化ICG研究在抗癌战斗中的影响，并利用哥伦比亚其他生物医学领域的现有优势领域。 因此，四个ICG计划中的每一个都旨在发展肥沃的研究环境以及实现重大科学进步所必需的关键质量。 无论如何，ICG在其研究和教学活动中都取得了巨大成功。 从同行评审的赠款中，其资金基础越来越多，这已经从1999年6月的约150万美元增长到目前批准的资金的约540万美元（包括九项RO1赠款，P01计划项目赠款，以及一项癌症生物学培训补助金）的540万美元。 当ICG于1999年成立时，在Russ Berrie Science Pavilion中将其分配到约15,500平方英尺的秋千空间。 这旨在是临时安排，直到ICG在未来的欧文癌症研究中心被移至其永久住所。 拟议的ICG搬迁到本网站将为现有的ICG实验室提供多个B，这些实验室在人员和资金中成长； ii）招募完成ICG研究计划所需的两个新教师； iii）实验室空间，可容纳所有哥伦比亚大学研究人员（即基因组学，蛋白质组学，细胞遗传学和病理学）的最新核心设施。 最后，将ICG搬迁至拟议的设施是哥伦比亚癌症研究活动的关键第一步，该活动是一座专门的建筑，即欧文癌症研究所。 这些设施将专门用于与我们的联邦和非联邦赠款提案的具体目的中概述的研究以及至少在未来20年内的研究/教学培训/教学的研究/教学。