TROPHIC FACTOR/TRANSMITTER INTERACTIONS IN ADDICTION

成瘾过程中营养因子/递质的相互作用

• 批准号: 2517979
• 负责人: Gerald D Fischbach
• 金额: $ 78.2万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2517979
• 关键词: drug abuse; neurotransmitter metabolism

This is a response to a NIDA RFA for the establishment of a Neuroscience Network. This proposal contains a series of highly interdigitated projects, connected both scientifically and technically. The major theme running through all four projects is the action of neurotrophic factors and cytokines in neural systems relevant to drug abuse. A second major theme running through three of the four projects is modulation of mesolimbic dopamine systems by neurotransmitters and trophic factors. A third theme binding two of the projects closely together is the study of cholinergic-dopaminergic interactions. The Network involves entirely new project from two labs already involved in drug abuse research and recruits the laboratories of two well established neuroscientists to drug abuse research for the first time. A major connection of all the investigators is their commitment to the use of molecular and cellular tools in the service of understanding brain and behavior. The investigators, who comprise a highly collegial group, well known to each other, are particularly enthusiastic about the communications core which will facilitate their work together. This RFA has provided an opportunity for the group to develop synergistic interactions across physical distance that will speed their investigations of fundamental processes in the nervous system relevant to the actions of drugs of abuse.

这是对建立神经科学的NIDA RFA的回应 网络。该提案包含一系列高度互连的 项目在科学和技术上都连接。主要主题 整个四个项目都是神经营养因素的作用 和与药物滥用有关的神经系统中的细胞因子。第二大专业 贯穿四个项目中的三个的主题是调制 神经递质和营养因子的中唇多巴胺系统。一个 第三个主题绑定了两个项目的研究是研究 胆碱能 - 多巴胺能相互作用。该网络涉及全新 来自已经参与药物滥用研究和新兵的两个实验室的项目 两位良好建立的神经科学家的实验室对滥用毒品 第一次研究。所有调查人员的主要联系 他们的承诺是使用分子和细胞工具 服务大脑和行为。调查人员，谁 一个众所周知的众所周知的众所周知的是 对通信核心特别热情 协助他们的工作。此RFA为 该小组跨物理距离发展协同互动 这将加快他们对中基本过程的调查 神经系统与滥用药物的作用有关。