VALIDATION OF MAGNETIC RESONANCE PERFUSION IMAGING

磁共振灌注成像的验证

• 批准号: 6193264
• 负责人: Jeffry R Alger
• 金额: $ 33.77万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6193264
• 关键词: bioimaging /biomedical imaging; cerebrovascular imaging /visualization; clinical research; diagnosis design /evaluation; diagnosis quality /standard; human subject; magnetic resonance imaging; perfusion; positron emission tomography; stroke

DESCRIPTION (Adapted from Applicant's Abstract): The aim is to optimize and validate the Magnetic Resonance Imaging (MRI) bolus passage perfusion technique in stroke victims. Recently discovered perfusion/diffusion MRI techniques are among the most promising developments in acute stroke care in this decade because they can potentially distinguish the ischemic core from surrounding hypoperfused but salvageable tissue. At present, the weakest component of the acute stroke MRI study is the perfusion study. There has been no direct demonstration that perfusion MRI accurately detects penumbral hypoperfusion by comparison with a "gold standard" method in stroke patients. No team has defined a recipe of optimal perfusion scanning parameters and then validated this recipe in stroke victims against a gold standard. There has been no direct validation of the usually-made assumption of a log-linear relationship between intravascular contrast agent concentration and MRI signal change. Likewise, no proven data analysis recipe has come forth. Oxygen-15 water Positron Emission Tomography (PET) blood flow assessment will be used as gold standard to validate perfusion MRI studies of stroke victims. MRI and PET assessment of blood flow will be made back-to-back. Medically stable stroke patients in the subacute epoch (< 48 hrs) will be studied. These patients are expected to display a wide range of blood flow values which will provide a high dynamic range over which to test the accuracy of perfusion MRI, yet be stable enough to undergo both studies. MRI perfusion scans using different MRI scanning parameters and analysis methods will be evaluated against the PET gold standard. Using the validated MRI procedures, a further pilot study is planned to explore whether MRI can accurately identify perfusion abnormalities and cerebrovascular reserve deficiencies in asymptotic subjects who have vascular risk factors for stroke. UCLA has new state-of-the-art MRI and PET imaging devices together with active collaborating teams having expertise in stroke clinical management (both acute and rehabilitative), in MRI scanning and in PET scanning.

描述（改编自申请人的摘要）：目的是优化和 确认磁共振成像（MRI）团注通道灌注技术 在中风患者中。最近发现的灌注/扩散MRI技术是 在这十年里，急性中风护理最有希望的发展之一， 因为它们可以潜在地区分缺血核心和周围的 低灌注但可挽救的组织目前， 急性卒中MRI研究是灌注研究。没有直接的 证明灌注MRI通过以下方式准确检测半影区灌注不足： 与中风患者的“金标准”方法进行比较。没有一支球队 定义了最佳灌注扫描参数的配方，然后进行验证 这个配方在中风患者中的应用没有直接的 验证通常假设的对数线性关系， 血管内造影剂浓度和MRI信号变化。同样，没有 经过验证的数据分析配方已经出现。氧-15水正电子发射 断层扫描（PET）血流评估将用作金标准， 验证中风患者的灌注MRI研究。MRI和PET评估 血液会连续流动医学上稳定的中风患者 将研究亚急性期（< 48小时）。预计这些患者 显示大范围的血流值，这将提供高动态 范围，在此范围内测试灌注MRI的准确性，但要足够稳定， 进行两项研究。使用不同MRI扫描的MRI灌注扫描 参数和分析方法将根据PET金进行评价 标准使用经验证的MRI程序，计划进行进一步的试点研究 探讨MRI是否可以准确识别灌注异常， 有血管病变的渐近受试者的脑血管储备不足 中风的危险因素加州大学洛杉矶分校拥有最先进的MRI和PET成像 设备与具有中风专业知识的积极合作团队 MRI扫描和PET中的临床管理（急性和康复） 扫描。